30天死亡率的风险因素在鼻性肠球菌血流感染中
Verena Zerbato1, Riccardo Pol1, Gianfranco Sanson2
1Infectious Diseases Unit, Trieste University Hospital (ASUGI), 34125 Trieste, Italy.
Antibiotics (Basel, Switzerland)
|July 27, 2024
概括
抗万科米辛的Enterococcus faecium血流感染 (BSI) 与更高的30天死亡率有关. 诸如年龄和复杂的细菌病等因素增加了风险,而传染病专家的咨询和适当的治疗改善了结果.
科学领域:
- 传染性疾病 传染性疾病
- 临床微生物学 临床微生物学
- 流行病学 流行病学
背景情况:
- 鼻腔血流感染 (BSI) 经常是由肠球菌引起的.
- 在全球范围内,抗万科素耐药性肠球菌 (VRE) BSI的发病率正在增加.
- 按Enterococcus物种分层,万科米辛耐药性和治疗对于理解BSI结果至关重要.
研究的目的:
- 评估肠球菌BSI和30天死亡率的风险因素.
- 根据Enterococcus物种,万科米辛耐药性和治疗适当性的结果进行分层.
- 确定肠球菌BSI患者死亡率的独立预测因素.
主要方法:
- 从2014-2021年进行的回顾性队列研究.
- 包括有阳性血液培养Enterococcus faecalis或Enterococcus faecium的成年患者.
- 多变量考克斯回归分析以确定死亡率预测因素.
主要成果:
- 整体30天死亡率为27.5%.
- 与E. faecalis BSIs (23.2%) 相比,抗万科素的E. faecium BSIs的死亡率更高 (36.6%).
- 独立的死亡率预测因素包括PITT得分,复杂的细菌病和年龄;减少的死亡率与男性性别,ID专家咨询和适当的治疗有关.
结论:
- 抗万科素的E. faecium细菌症独立地与30天死亡率的增加有关.
- 适当的治疗和传染病咨询与死亡率的降低有关.
- 肠球菌种类和万科菌素耐药性显著影响BSI结果.
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