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葡萄牙从Gerês提取物对抗病原性微生物的体外抗菌潜力
Rafaela Dias Oliveira1,2, Carina Araújo3, Cristina Almeida-Aguiar3,4
1Life and Health Sciences Research Institute (ICVS), University of Minho, 4710-057 Braga, Portugal.
来自Gerês的葡萄牙蜂对抗耐药细菌表现出显著的抗菌活性. 这种天然产品为打击抗菌素耐药性 (AMR) 提供了一个有前途的替代方案,这是一个主要的全球健康问题.
科学领域:
- 微生物学 微生物学
- 自然产品 化学 化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗菌素耐药性 (AMR) 是一个日益严重的全球卫生危机,微生物对现有抗生素的耐药性日益增加.
- 天然产品,如,正在研究其潜在的抗菌特性,作为传统治疗的替代品.
研究的目的:
- 评估来自Gerês蜂巢的葡萄牙的体外抗菌潜力.
- 评估水醇提取物对一组细菌和酵母的疗效,包括抗生素耐药菌株.
主要方法:
- 从单个样本中制备五种醇提取物,从混合物中制备一个.
- 确定最小抑制度 (MIC) 对抗格拉姆阳性细菌 (Bacillus subtilis,金黄色葡萄球菌 (MSSA和MRSA)),格拉姆阴性细菌 (大肠杆菌) 和酵母菌 (Candida albicans,Saccharomyces cerevisiae).
- 盘扩散试验比较提取物与商业抗生素 (素,素,阿莫西西林/克拉夫兰酸).
主要成果:
- прополис提取物表现出度依赖的抗菌作用.
- 醇提取物显示出优越的抗菌能力,相比于万科米辛对抗B. subtilis和MSSA.
- 甲素耐药金黄色葡萄球菌 (MRSA) 对提取物敏感,但对所有测试的抗生素都耐药.
结论:
- 来自格雷斯蜂群的蜂在体外表现出显著的抗菌活性.
- 这些发现凸显了作为一种有前途的天然剂,用于打击抗菌素耐药性.
- 对Gerês的进一步研究可能会导致针对耐药微生物感染的新型治疗策略.
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