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选择性激活脊髓与外围电刺激脊髓

Carlos Cuellar¹, Lauri Lehto², Riaz Islam³

¹School of Sport Sciences, Universidad Anáhuac México, Huixquilucan 52786, Mexico.

|July 27, 2024

概括

新的脊髓外周电刺激 (EES) 方法,空间选择性刺激 (SSES) 和定向选择性外周刺激 (OSES),与传统方法相比,可以更好地控制运动反应. 这些技术提高了脊髓神经调节的选择性.

科学领域:

神经科学是一个神经科学.
生物医学工程生物医学工程
神经外科神经外科

背景情况:

脊髓外周电刺激 (EES) 用于慢性疼痛和脊髓损伤的恢复.
目前的EES有效性受到低于最佳的电极放置和空间选择性差的限制.
开发有针对性的刺激对于优化神经调节结果至关重要.

研究的目的:

为了比较空间选择性刺激 (SSES) 和定向选择性外周刺激 (OSES) 与传统单极外周刺激 (CMES) 的疗效.
评估不同EES范式对脊柱引起的运动潜能 (SEMP) 的影响.
确定SSES和OSES是否提供增强的空间选择性和对神经调节的控制.

主要方法:

在动物模型中利用了SSES和OSES范式的3或4接触电极阵列.
将SSES和OSES与传统单极外周刺激 (CMES) 进行比较.
在不同的刺激方式中测量了脊柱引起的运动潜能 (SEMP) 的幅度和延迟.

主要成果:

后肢肌肉中的SEMP振幅因电场方向和刺激方式而异.
与CMES相比,SSES和OSES对SEMP振幅的控制更具选择性.
该研究证实,SSES和OSES范式提供了对神经调节的可调节控制.

结论:

与CMES相比,SSES和OSES范式提供了更好的空间选择性和对脊髓刺激的控制.
这些先进的EES方法可以根据功能性脊髓神经解剖学和特定的向纤维量身定制.
优化的EES方法,如SSES和OSES,有望改善慢性疼痛和脊髓损伤的治疗.

关键词:

皮外线刺激皮外线刺激功能性神经解剖学功能性神经解剖学通过神经调节进行神经调节.导向 - 选择性刺激疼痛疼痛疼痛疼痛鼠类鼠类鼠类鼠类鼠类空间选择性刺激的空间选择性刺激脊髓损伤导致的脊髓损伤脊髓刺激脊髓刺激旋转式唤起的电机潜力

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