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作为神经保护调节剂的英多尔-3-碳醇及其衍生物

Alka Ashok Singh¹, Dhananjay Yadav¹, Fazlurrahman Khan^2,3

¹Department of Life Sciences, Yeungnam University, Gyeongsan 38541, Republic of Korea.

|July 27, 2024

概括

印醇-3-碳醇 (I3C) 和二醇甲 (DIM) 通过激活来自大脑的神经营养因子 (BDNF) 途径和抗氧化防御来显示神经保护作用,为神经退行性疾病提供了有前途的策略.

科学领域:

神经科学是一个神经科学.
分子生物学分子生物学
药理学药理学是指药理学的学科.

背景情况:

大脑衍生神经营养因子 (BDNF) 和其TrkB通路对于抗抑郁药的作用和神经元健康至关重要.
氧化应激 (OS) 驱动神经退行和衰老,而Nrf2-ARE系统是一个关键的防御.
功能障碍的TrkB信号传递与大脑疾病有关,突出显示TrkB和Nrf2作为治疗点.

研究的目的:

审查植物化学品的治疗潜力,特别是I3C和DIM,用于神经退行性疾病.
探索I3C和DIM如何通过BDNF-TrkB和Nrf2-ARE通路激活神经元防御机制.
强调神经元防御系统的联合激活作为一种新的治疗策略.

主要方法:

对BDNF,TrkB,Nrf2-ARE信号传递和神经退行症中的氧化应激现有文献的综述.
分析I3C和DIM调节这些通路的机制.
专注于TrkB信号传递,Akt酸化和Nrf2激活之间的相互作用.

主要成果:

BDNF-TrkB信号激活了Nrf2-ARE通路,从而赋予了对OS的神经保护.
I3C和DIM模仿BDNF活动,诱导Akt酸化并激活抗氧化防御.
这些植物化学物质阻断Nrf2-Keap1复合体,促进Nrf2核转位和Nrf2-ARE介导的基因表达.

结论:

通过同时激活神经元防御机制,I3C和DIM显示出显著的神经保护潜力.
用植物化学品向TrkB激活和Nrf2-ARE系统,为神经退行性疾病提供了一个有前途的治疗策略.
对I3C衍生物的进一步研究可能会导致与氧化应激和神经退行相关的疾病的新疗法.

关键词:

抗抑郁药物抗抑郁药物抗抑郁药物衍生品是一种衍生品.印-3-碳醇是一种醇.这是一种神经退行性疾病.神经保护性神经保护剂氧化应激是一种氧化应激.

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