适应性体力活动对精神分裂症患者白质完整性的影响
Elise Leroux1, Laura Masson1, Maxime Tréhout1,2
1"Physiopathology and Imaging of Neurological Disorders" PhIND, UMR-S U1237, INSERM, GIP Cyceron, 14000 Caen, France.
Brain sciences
|July 27, 2024
概括
远程适应体力活动 (e-APA) 改善了精神分裂症患者的白质 (WM) 完整性. 减少负面症状与增强的WM完整性有关,这表明e-APA是一种有前途的治疗策略.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 康复科学 康复科学 康复科学
背景情况:
- 精神分裂症与白质 (WM) 完整性变化和预期寿命缩短有关,部分原因是抗精神病性心脏代谢副作用.
- 身体活动 (PA) 是一种安全有效的生活方式干预.
- 远程交付PA程序提供了一个可扩展的方法来管理慢性疾病.
研究的目的:
- 评估远程传递的适应体力活动 (e-APA) 计划对精神分裂症患者 (SZPs) 和健康对照 (HCs) 的WM完整性的影响.
- 评估SZPs中WM完整性,心肺健康和临床症状严重程度的变化之间的关联.
主要方法:
- 一项为期16周的纵向研究,涉及31名参与者 (18名SZP,13名HC).
- 扩散张力成像 (DTI) 和基于通道的空间统计 (TBSS) 用于测量WM完整性.
- 通过最大氧气摄取量 (VO2max) 和使用积极和消极综合征量表,消极症状自我评估和简短消极综合征量表 (BNSS) 的临床症状来评估心肺呼吸能力.
主要成果:
- 经过e-APA程序后,SZPs在WM完整性中显示出显著的改善,包括增加分数异构性和减少与运动和语言相关的囊中的辐射扩散性.
- 在HC中没有观察到显著的WM完整性变化.
- 在SZPs中降低负面症状 (BNSS) 与WM完整性的更大改善有关.
结论:
- 电子APA计划显示了改善精神分裂症患者WM完整性异常的潜力.
- 电子APA可以作为一种有价值的治疗策略,以补充现有的精神分裂症治疗方法,解决身体和神经方面的问题.
- 这些发现突显了精神分裂症中身体活动,大脑结构和症状严重程度的相互联系.
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