希腊和西班牙橄叶的抗氧化提取物:抗微生物,抗癌和抗血管效应
Ioana Zinuca Magyari-Pavel1, Elena-Alina Moacă2,3, Ștefana Avram1
1Department of Pharmacognosy, "Victor Babeș" University of Medicine and Pharmacy Timișoara, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.
Antioxidants (Basel, Switzerland)
|July 27, 2024
概括
来自西班牙和希腊的橄叶提取物显示出作为抗微生物和抗癌剂的潜力. 这些植物药物具有很高的抗氧化能力和抗入侵性质,特别是对黑色素瘤细胞.
科学领域:
- 植物医学 植物医学
- 自然产品 化学 化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 包括初橄油在内的Olea europaea L. (橄树) 产品与降低心血管疾病和癌症风险有关.
- 橄叶是一种农业副产品,是新型植物医药的有希望的来源.
- 橄叶 (Olivae folium) 的乙醇提取物正在研究其治疗潜力.
研究的目的:
- 描述和比较两种来自西班牙 (OFS) 和希腊 (OFG) 橄叶的乙醇提取物.
- 评估这些提取物的抗氧化,抗微生物,细胞毒性和抗血管性质.
- 通过使用蛋试验 - 胆质膜 (HET-CAM) 试验来评估提取物的安全性和耐受性.
主要方法:
- 从西班牙 (OFS) 和希腊 (OFG) 的橄叶中制备两个乙醇提取物.
- 基因化合物 (例如,oleuropein,lutein) 和五环三烯 (例如,oleanolic 酸,maslinic 酸) 的量化.
- 对抗氧化能力,对Streptococcus pyogenes的抗菌活性,对A375黑色素瘤细胞的选择性细胞毒性和对CAM的抗血管性潜力进行了测试.
主要成果:
- 这两种提取物都含有大量的化合物和三烯,OFG的度更高.
- 抗氧化能力与OFG相似,在OFG中略高,可能是由于金属聚复合物.
- 提取物在较高剂量下表现出抗微生物作用,特别是在对抗格拉姆阳性细菌.
- 含有较低无机成分和较高生物活性化合物的提取物表现出强烈的抗激素,选择性细胞毒性,抗迁移性和抗血管性作用.
- 在体内测试 (HET-CAM) 表明没有易怒性和良好的耐受性.
结论:
- 橄叶提取物富含多和三烯,具有显著的抗氧化和抗菌活性.
- 这些提取物显示出有希望的选择性细胞毒性,抗迁移性和抗血管原体,特别是针对黑色素瘤.
- 这些发现支持橄叶产品在医疗保健中作为抗微生物和抗癌治疗的潜在用途.
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