食蛋白酶补充剂通过调节肠道屏障,免疫反应和微生物群组成改善了断奶小猪的生长性能和营养消化
Tao Liu1,2, Wen Ma1, Jun Wang1
1State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Antioxidants (Basel, Switzerland)
|July 27, 2024
概括
食蛋白酶补充剂通过增强肠道健康和有益的肠道细菌,改善了断奶小猪的生长. 这项研究揭示了除了蛋白质消化之外的蛋白质酶益处,影响免疫力和肠道屏障功能.
科学领域:
- 动物营养和生理学
- 胃肠道微生物学 胃肠道微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 饮食中蛋白质酶的益处已得到认可,但除了蛋白质降解之外的机制仍然不清楚.
- 了解蛋白酶对断奶小猪生理学的影响,对于优化营养至关重要.
- 研究蛋白酶对生长,肠道功能和肠道微生物群的影响是有必要的.
研究的目的:
- 调查食蛋白酶对断奶小猪生长表现的影响.
- 评估蛋白酶对肠道形态,屏障完整性和抗氧化能力的影响.
- 分析蛋白酶补充后肠道微生物组成和炎症反应的变化.
主要方法:
- 90只断奶小猪被食控制,负控制 (没有酶) 或蛋白质酶补充饮食28天.
- 评估了生长性能,血清抗氧化能力 (T-AOC),甲和炎症标志物 (TNF-α,IL-1β,IL-6).
- 分析了肠道形态,屏障蛋白表达 (ZO-1,Occludin,Claudin-1),状炎症基因表达和肠道微生物群组成.
主要成果:
- 蛋白酶添加显著提高了生长性能和增强了抗氧化能力 (T-AOC),同时减少了甲.
- 血清炎症标志物和关前炎症基因表达减少;MAPK和NF-κB通路被抑制.
- 肠道形态和屏障完整性得到改善,有益细菌 (Lachnospiraceae,Prevotellaceae) 增加,有害细菌 (Terrisporobacter) 减少.
结论:
- 食蛋白酶补充剂对断奶小猪的生长性能产生了积极的影响.
- 蛋白酶的益处与改善肠道屏障完整性,增强免疫反应和有利的肠道微生物群转移有关.
- 蛋白酶添加提供了一种可行的策略,可以改善小猪的健康和表现,而不仅仅是简单的蛋白质消化.
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