听力损失和氧化应激:一个全面的审查
A Maniaci1,2,3, L La Via4, J R Lechien3,5,6,7
1Faculty of Medicine and Surgery, University of Enna Kore, 94100 Enna, Italy.
Antioxidants (Basel, Switzerland)
|July 27, 2024
概括
氧化应激显著导致各种形式的听力损失. 抗氧化剂疗法在预防和治疗这种损伤方面表现有前途,为改善听力健康提供了新的希望.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 神经科学是一个神经科学.
- 生物化学 生物化学
背景情况:
- 听力损失影响全球数百万人,并且越来越多地与氧化压力有关.
- 反应性氧物种 (ROS) 在耳损伤和听觉系统功能障碍中起着至关重要的作用.
- 耳的高新陈代谢率和有限的血液供应使其易受氧化损伤的影响.
研究的目的:
- 综合审查氧化应激和听力损失之间的关系.
- 探索听力系统中氧化损伤的机制.
- 评估抗氧化剂干预措施对听力损失的有效性.
主要方法:
- 对有关氧化应激和听力损失的现有文献进行系统审查.
- 对研究ROS在耳损伤中的研究分析.
- 对抗氧化剂治疗和其他干预措施的数据的评估.
主要成果:
- 氧化应激与与年龄相关的,噪音引起的和耳毒性听力损失有关.
- 抗氧化剂治疗在临床前和临床研究中显示出减轻听力损失的潜力.
- 新的方法如向药物输送和基因疗法正在出现.
结论:
- 氧化应激是多种类型听力损失的关键因素.
- 抗氧化剂干预提供了一个有希望的治疗途径.
- 对个性化治疗的进一步研究对于有效的听力损失管理至关重要.
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