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超声波皮层发育和胎儿的异常:系统性审查和元分析
Ilenia Mappa1, Daniele Di Mascio2, Luigi Carbone3
1Department of Obstetrics and Gynecology, Fondazione Policlinico Tor Vergata, University of Rome Tor Vergata, 00133 Rome, Italy.
Biomedicines
|July 27, 2024
概括
这一系统性审查详细介绍了胎儿脑裂在超声波上的发展,发现大多数裂在妊娠24周时可见. 皮层形通常与其他中枢神经系统异常有关.
科学领域:
- 产前成像和胎儿神经发育.
- 医学诊断和超声波技术.
背景情况:
- 准确评估胎儿大脑发育对于识别潜在的神经异常至关重要.
- 了解胎儿大脑裂形成的典型时间表有助于诊断皮质形.
研究的目的:
- 系统地审查和报告通过超声波可视化的胎儿大脑裂的正常发展.
- 描述胎儿与皮质形相关的异常.
- 评估现有的胎儿皮层发育参考图的质量.
主要方法:
- 系统性审查包括27项研究,涉及6875名胎儿.
- 用比例的元分析来结合关于裂可视化时间和异常关联的数据.
- 纳入标准集中在报告发育,异常的研究和超声波胎儿皮层结构的参考图表上.
主要成果:
- 塞尔维亚裂在怀孕24周时几乎所有胎儿中都可见.
- 围和骨裂呈现渐进的可视化,在24周后几乎可以普遍检测到.
- 皮层发育的形仅在6.21%的病例中被孤立,其中93.79%与额外的中枢神经系统异常有关.
结论:
- 在超声波上可视化胎儿大脑裂的确定的时间表为正常发育提供了一个基准.
- 皮质形与其他中枢神经系统异常的高度关联凸显了这些疾病的复杂性.
- 需要进一步的大规模研究 sulci 发育和标准化产前评估算法.
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