在没有并发症的1型糖尿病的年轻患者皮肤氧化的性别相关差异
Jolanta Neubauer-Geryk1, Małgorzata Myśliwiec2, Leszek Bieniaszewski1
1Clinical Physiology Unit, Medical Simulation Centre, Medical University of Gdańsk, 80-210 Gdańsk, Poland.
Biomedicines
|July 27, 2024
概括
性别影响1型糖尿病儿童的微循环. 女性的休息氧气水平较高,但毛细管镜检查结果在两性之间相似,这凸显了糖尿病研究中需要考虑性别的必要性.
科学领域:
- 内分泌学 在内分泌学.
- 儿科 儿科 儿科
- 生理学 生理学 生理学
背景情况:
- 性别显著改变了疾病的表现和进展.
- 糖尿病在发病率,发病率和死亡率上表现出明显的基于性别的差异.
- 糖尿病会影响微血管功能,并可能产生性别特异性的影响.
研究的目的:
- 调查性别对1型糖尿病儿科患者皮肤微循环的影响.
- 为了确定性别是否会影响毛细管透视和透皮氧和结果.
- 测试性别是解释糖尿病儿童微循环参数的关键因素的假设.
主要方法:
- 这是一项涉及42名1型糖尿病不复杂的男孩和55名女孩的横截面研究.
- 性别之间的人口,代谢和微循环参数的比较.
- 在外围封闭反应性高血压 (PORH) 试验期间评估基底毛细管学参数和血管反应性.
主要成果:
- 在年龄,糖尿病发病,持续时间或代谢控制方面没有显著的性别差异.
- 与男性相比,女性的血压较低,脉较高,心率较高.
- 女性的肌素和血红蛋白水平明显较低;休息时的透皮部分氧气压在女性比男性更高.
- 在PORH测试期间,在基底毛细管学参数或血管反应性中没有观察到与性别相关的差异.
结论:
- 性别是影响1型糖尿病儿童和青少年微循环参数的重要因素.
- 虽然休息时的氧和量因性别而异,但毛细血管检查和血管反应性在这个队列中没有显示基于性别的变化.
- 未来的糖尿病微循环研究应该考虑到性别以及其他已确定的辅助因子.
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