暴露于挥发性有机化合物可能会导致成年人的亚托皮炎
Kuo-Tung Tang1,2,3, Yu-Sin Chen4,5, Mey-Fann Lee6
1Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, Taichung 407, Taiwan.
Biomedicines
|July 27, 2024
概括
患有无形性皮肤炎 (AD) 的成年人表现出尿液中某些挥发性有机化合物 (VOC) 的水平升高,包括多和1,3-丁代谢物. 这些VOC可能有助于AD的发展.
科学领域:
- 环境健康 环境健康
- 皮肤病学 皮肤病学
- 毒理学 毒理学 毒理学
背景情况:
- 挥发性有机化合物 (VOC) 是室内空气污染的重要因素.
- 以前的研究将VOC暴露与过敏状况联系起来.
- 挥发性有机化合物与成人亚托皮炎 (AD) 之间的关联需要进一步调查.
研究的目的:
- 调查暴露于VOC与成年人中亚型皮肤炎 (AD) 患病率之间的关系.
- 在成人AD患者和健康对照中量化特定的VOC代谢物.
主要方法:
- 预期招募31名成人AD患者和11名健康对照组.
- 尿液中的VOC代谢物 (1,3-丁,,,等等) 的量化. 使用液体染色学-质谱学.
- 多变量线性回归分析和实验室刺激小鼠骨髓衍生细胞 (BMMCs) 具有特定的VOCs.
主要成果:
- 在AD患者中观察到尿液中N-Acetyl-S-() -L-cysteine (BMA) 和N-Acetyl-S-(3,4-dihydroxybutyl) -L-cysteine (DHBMA),分别是和1,3-butadiene的代谢物水平升高.
- 暴露于1,3-二烯和二烯在体外刺激了BMMC脱粒化.
- 虽然观察到趋势,但BMA和DHBMA的多重比较校正后的统计学意义没有达到.
结论:
- 某些挥发性有机化合物,特别是1,3-丁和,可能在成人亚托皮炎的发病过程中发挥作用.
- 需要进一步的研究来证实这种关联并阐明机制.
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