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Updated: Jun 19, 2025

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage
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Published on: January 31, 2018

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CX-5461优先诱导在核糖体DNA位点的Top2α-依赖DNA断裂

Donald P Cameron1,2, Jirawas Sornkom2,3, Sameerh Alsahafi4

  • 1ACRF Department of Cancer Biology and Therapeutics, Division of Genome Sciences and Cancer, The John Curtin School of Medical Research, The College of Health and Medicine, The Australian National University, Canberra, ACT 2601, Australia.

Biomedicines
|July 27, 2024
PubMed
概括

RNA聚合酶I抑制剂CX-5461触发了核糖体DNA促进体的DNA损伤,这种损伤是由2α多聚合酶介导的. 这种有针对性的机制为癌症治疗提供了一个有希望的非基因毒性方法.

关键词:
在CX-5461中使用.的DNA损伤途径.的RNA聚合酶I.双链断裂是因为双链断裂.核核监测路径 核核监测路径在p53中,p53是什么?核糖体生物发生的生物生成.毒酶酶的使用方法

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