炎症性肠病中的精准医学:聚焦新兴分子生物标志物的焦点
Antonio Mestrovic1, Nikola Perkovic1, Dorotea Bozic1
1Department of Gastroenterology, University Hospital of Split, Spinciceva 2, 21000 Split, Croatia.
新的生物标志物对于诊断和管理炎症性肠病 (IBD) 是至关重要的. 研究正在确定新型标记物,但在有效的IBD患者护理的特异性和可访问性方面仍然存在挑战.
科学领域:
- 胃肠病学 胃肠病学
- 生物标志物发现发现
- 分子诊断学 分子诊断学
背景情况:
- 炎症性肠病 (IBD) 存在诊断和管理方面的挑战.
- 目前的诊断工具,如C-反应蛋白 (CRP) 和便calprotectin在特异性方面存在限制.
- 侵入性内镜手术是标准的,但强调了对非侵入性替代品的需求.
研究的目的:
- 审查现有的IBD生物标志物和诊断方法的局限性.
- 探索新兴的生物标志物和技术,以改善IBD检测和监测.
- 强调需要新的,非侵入性标记物来进行个性化的IBD管理.
主要方法:
- 对IBD研究近期进展的文献综述.
- 从蛋白质学,表观遗传学和肠道微生物群研究中分析新兴生物标志物候选者.
- 评估新诊断技术及其临床适用性.
主要成果:
- 已经确定了几种新的潜在生物标志物 (例如,BAFF,PGE-MUM,oncostatin M,microRNA面板,αvβ6抗体,S100A12).
- αvβ6抗体和哥斯塔丁M显示出临床应用的希望.
- 挑战包括标记物特异性和微RNA等检测技术的成本/可访问性.
结论:
- 新型生物标志物对于推进IBD诊断,风险预测和治疗反应至关重要.
- 尽管取得了进展,但对于广泛的临床采用,必须解决特异性和可访问性方面的挑战.
- 开发非侵入性,全面的标记物对于优化IBD患者护理至关重要.
更多相关视频
09:01Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice
Published on: March 10, 2015
10:37Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
Published on: November 30, 2016
相关概念视频
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
