维生素D补充可以改善复发性复发性硬化症患者的炎症吗?
Martyna Lis1, Natalia Niedziela1, Jowita Adamczyk-Zostawa2
1Department of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.
Biomedicines
|July 27, 2024
概括
多发性硬化症 (MS) 患者的维生素D补充剂没有显著降低炎症标志物. 该研究表明,目前的剂量可能太低,无法在复发性复发性多发性硬化症 (RRMS) 中对炎症产生有益影响.
科学领域:
- 神经免疫学 神经免疫学
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 维生素D (VitD) 正在研究其在多发性硬化症 (MS) 中潜在的抗炎性质.
- 炎症在MS的发病和进展中起着关键作用.
- 了解VitD对炎症标志物的影响对于管理MS至关重要.
研究的目的:
- 评估不同口服维生素D (VitD) 补充剂剂对复发性复发性多发性硬化症 (RRMS) 患者的炎症标志物的影响.
- 评估血清25OH) D水平的变化及其与炎症标志物的相关性.
- 确定VitD补充是否可以调节RRMS中的关键炎症细胞因子.
主要方法:
- 一项为期6个月的研究涉及52名RRMS患者,分为高剂量 (HD) 和低剂量 (LD) VitD组.
- 患HD组每天接受2000 IU,而LD组每月接受15960 IU.
- 评估血清25(OH) D水平的变化以及各种炎症标志物 (例如IL-4,IL-6,IL-17A,TNF-α,IL-10,IL-23).
主要成果:
- 血清25(OH) D水平在两组中都显著增加,在HD组的增加更大.
- 尽管服用补充剂,但很大一部分患者仍然缺乏或缺乏VitD.
- 观察到促炎性细胞因子 (IL-6,IL-17A,TNF-α) 的显著增加和IL-10的减少,这表明抗炎作用有限.
- 发现了25(OH) D和sCD40L/TNF-α之间的初始正相关性,以及与IL-23.3的负相关性.
结论:
- 服用的维生素D (VitD) 剂量可能不足以引起RRMS患者显著的抗炎作用.
- 需要进一步的研究,以建立最佳的VitD剂量策略来控制MS的炎症.
- 该研究强调了VitD在MS中的作用的复杂性以及需要更高剂量或不同的治疗方法.
相关概念视频
T Cell Types and Functions
967
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
967
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
331
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
331
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
149
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
149
Role of Vitamins in Maintaining Bone Health
3.2K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.2K
Inflammatory Bowel Disease IV: Pharmacological Management
124
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
124


