在早产婴儿中使用心率或血压进行脑血管自调节:试点研究
Bineta E Lahr1, Celina L Brunsch1, Riksta Dikkers2
1Department of Neonatology, Beatrix Children's Hospital, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.
Children (Basel, Switzerland)
|July 27, 2024
概括
心率 (HR) 和平均动脉血压 (MABP) 为早产婴儿的脑血管自调节 (CAR) 提供了不同的评估. 这些方法在这个脆弱人群中评估CAR是不可互换的.
科学领域:
- 新生儿生理学 新生儿生理学
- 大脑血管调节的调节
- 医疗监测 医疗监测 医疗监测
背景情况:
- 脑血管自调节 (CAR) 对早产婴儿的大脑发育至关重要.
- 持续的CAR评估通常需要侵入性平均动脉血压 (MABP) 监测.
- 需要非侵入性的CAR评估替代方案.
研究的目的:
- 为了比较脑血管自身调节 (CAR) 评估使用心率 (HR) 与早产婴儿的MABP.
- 评估基于HR的CAR指数 (TOHRx) 与基于MABP的指数 (COx) 的可靠性.
主要方法:
- 使用移动窗口相关系数与大脑氧化和度 (rcSO2) 的CAR比较.
- 在出生后的前72小时内,使用HR (TOHRx) 和MABP (COx) 来计算CAR受损时间的百分比 (%timeCARi).
- 评估了CAR指数与短期脑损伤之间的关联.
主要成果:
- 在出生后的前两天,COx和TOHRx相关系数显著不同.
- 在1日和3日,MABP (COx) 的%TimeCARi比HR (TOHRx) 高.
- 这两种方法在很大一部分时间同时表明CAR受损,但与早期脑损伤无关.
结论:
- 心率 (HR) 和MABP在评估早产婴儿的CAR方面是不可互换的.
- 需要进一步的研究来验证非侵入性CAR监测方法.
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