与儿童肠道微生物组失调相关的神经发育障碍
Alejandro Borrego-Ruiz1, Juan J Borrego2,3
1Departamento de Psicología Social y de las Organizaciones, Universidad Nacional de Educación a Distancia (UNED), 28040 Madrid, Spain.
Children (Basel, Switzerland)
|July 27, 2024
概括
人的肠道微生物群早期形成,并影响大脑发育. 干扰与神经发育障碍 (NDD) 有关,提供潜在的未来治疗点.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
背景情况:
- 人的肠道微生物组从子宫内开始发展,并在生命早期成熟.
- 诸如分娩方式,养和压力等因素会影响微生物组的组成.
- 肠道微生物组-大脑轴通过神经,内分泌和免疫系统促进双向通信.
研究的目的:
- 审查有关肠道微生物群对早期大脑发育的影响的证据.
- 探索肠道微生物群与神经发育障碍 (NDD) 之间的相关性.
主要方法:
- 最近科学证据的文献综述.
- 对将肠道微生物组变化与NDD联系起来的研究进行分析.
主要成果:
- 肠道微生物组及其代谢物在调节早期大脑发育方面发挥着重要作用.
- 在发育过程中肠道微生物群的干扰会对大脑功能产生不利影响.
- 审查的特定NDD包括自闭症谱系障碍,多动症,图雷特综合征,脑和遗传综合征.
结论:
- 了解NDD的肠道微生物组变化至关重要.
- 这种知识可能为NDD打开新的治疗途径.
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