不同的红细胞储存解决方案和条件对细胞功能和活力的影响:系统性审查
Linh Nguyen T Tran1, Cristina González-Fernández1,2, Jenifer Gomez-Pastora1
1Department of Chemical Engineering, Texas Tech University, Lubbock, TX 79409, USA.
Biomolecules
|July 27, 2024
概括
优化红细胞 (RBC) 储存溶液可以提高细胞活力. 先进的解决方案和条件尽量减少存储损伤,提高输血结果,满足临床需求.
科学领域:
- 血液银行和输血医疗服务
- 细胞的保存和储存.
- 生物化学和血液学
背景情况:
- 红血细胞 (RBC) 储存解决方案已经演变为改善细胞在低温储存期间的活力和功能.
- 维持红细胞完整性需要平衡pH值,新陈代谢,氧化和透调节.
研究的目的:
- 综合审查和分析各种RBC存储解决方案和条件对关键RBC参数的影响.
- 为了比较不同的储存配方,包括基本和高级添加剂溶液 (ASs),以保持红细胞完整性的有效性.
- 调查储存条件对储存损伤积累的影响.
主要方法:
- 系统地比较各种RBC存储解决方案 (例如PBS,AS-7,PAGGSM).
- 对关键红细胞参数的分析:腺三酸盐 (ATP) 水平,形态学和血液溶解.
- 储存条件的调查:温度,氧化,抗凝剂,辐射和加工方法.
主要成果:
- 先进的性溶液可以存储红细胞长达8周,尽管某些代谢和形态恶化是不可避免的.
- 储存条件显著影响储存损伤的积累.
- 个性化的红细胞储存解决方案显示出减少病变和改善输血结果的希望.
结论:
- 优化红细胞储存解决方案和条件对于提高输血疗效至关重要.
- 个性化的保存介质,通过omics分析进行分析,可以最大限度地提高输血后红细胞的存活率和功能.
- 需要继续进行研究,以满足血液储存中不断变化的临床需求.
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