对吸烟和饮酒的客观评估在预测表观遗传衰老变异方面优于临床表型
Robert Philibert1,2, Man-Kit Lei3,4, Mei Ling Ong4
1Department of Psychiatry, University of Iowa, Iowa City, IA 52242, USA.
Genes
|July 27, 2024
概括
像PC-GrimAge和DunedinPACE这样的表观遗传衰老 (EA) 加速指数提供了除了吸烟和饮酒之外的有限的临床见解. 心脏代谢因素独特地预测PACE,这表明EA工具对患者护理有局限性.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 老年学是一门学科.
- 生物标志物 生物标志物
背景情况:
- 除了吸烟/饮酒之外,表观遗传衰老 (EA) 加速指数与临床表型的可靠性尚不清楚.
- 大多数EA研究使用欧洲祖先数据,限制了概括性.
研究的目的:
- 评估PC-GrimAge和DunedinPACE与非洲裔美国人的临床表型的关联.
- 评估EA指数作为临床查工具的有用性和局限性.
主要方法:
- 对278名中年非洲裔美国成年人的临床,生理和表观遗传评估.
- 用各种健康变量对PC-GrimAge和DunedinPACE进行回归分析.
主要成果:
- 年龄,性别,吸烟和饮酒预测了PC-GrimAge加速的74%,其他因素提供了最小的改善.
- 心脏代谢综合征变量独立预测了PACE值.
- PC-GrimAge和PACE的相关性很低 (r=0.2),有明显的差异解释.
结论:
- 表观遗传衰老指数可能提供不同的临床信息,并且对患者护理查有局限性.
- 在PC-GrimAge和PACE指数中,除了生活方式因素之外,还可以捕捉到不同的生物信息.
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