相关实验视频

Updated: Jun 19, 2025

Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib

Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib

Published on: June 26, 2019

在肺腺癌中 lncRNAs 和药物耐受性之间的潜在联系

William J H Davis^1,2, Catherine J Drummond^1,2, Sarah Diermeier^3,4

¹Department of Pathology, Dunedin School of Medicine, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand.

|July 27, 2024

概括

肺癌中耐药性持久体 (DTPs) 通过进入休眠状态而在向治疗中存活. 长非编码RNAs (lncRNAs) 可能有助于这种耐药性和最终的耐药性.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

向治疗对肺癌是有效的,但往往会导致由于耐药性导致复发.
药物耐药性部分是由耐药性持久细胞 (DTPs) 介导的,DTPs是休眠的,循环缓慢的癌细胞.
DTPs表现出类似干细胞的特征,表观遗传变化,改变的新陈代谢和增加的突变率.

研究的目的:

审查长非编码RNAs (lncRNAs) 在肺癌中耐药性生物学中的潜在作用.
探索 lncRNAs 如何为 DTPs 的特征作出贡献.
讨论 lncRNAs 对向治疗耐受性和耐药性的影响.

主要方法:

文献综述侧重于DTPs中的转录性变化.
对癌症表型中非编码RNA的现有研究进行分析.
综合有关lncRNAs和耐药性机制的当前知识.

主要成果:

以前的研究主要集中在编码蛋白质的基因上,忽视了非编码RNA.
长非编码RNAs (lncRNAs) 涉及与DTPs相关的表型.
lncRNAs可能在DTPs的生存和耐药性的发展中发挥重要作用.

结论:

lncRNAs可能有助于关键的DTP特征,包括休眠状态和茎状.
了解 lncRNA 功能可能会揭示针对药物耐受性的新治疗策略.
lncRNAs是肺腺癌对向治疗和耐药性演变的反应的关键参与者.

关键词:

获得的耐药性获得的耐药性药物耐受性耐药性药物耐受性在ncRNA中,我们可以肺部腺癌瘤是什么有针对性的治疗.

更多相关视频

Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression

Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression

Published on: January 19, 2019

Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma

Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma

Published on: March 3, 2023

相关概念视频

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

Treatment Resistant Cancers

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

Tissue-Drug Binding: Localization of Drugs and its Significance

Tissue-Drug Binding: Localization of Drugs and its Significance

Body tissues, comprising approximately 40% of the body weight, are crucial in drug distribution and localization. These tissues can serve as drug storage sites, competing with plasma binding sites for drug molecules.
Drugs can bind to different tissue components, enhancing their distribution and localization. The factors influencing drug localization in tissues include the drug's lipophilicity, structural characteristics, tissue perfusion rate, and pH differences. These factors determine...