控制的缺氧急性地防止身体不活动引起的外周BDNF下降
Yves Duderstadt1,2,3, Stefanie Schreiber2,4,5,6,7, Johannes Burtscher8
1Division of Cardiology and Angiology, University Hospital Magdeburg, 39120 Magdeburg, Germany.
International journal of molecular sciences
|July 27, 2024
概括
控制的正常性缺氧 (NH) 可以抵消由身体不活动引起的大脑衍生神经营养因子 (BDNF) 的下降. 这凸显了活跃的生活方式对于维持BDNF水平的重要性.
科学领域:
- 神经科学和生理学 神经科学和生理学
- 人体生理学 人体生理学
- 生物化学 生物化学
背景情况:
- 大脑衍生神经营养因子 (BDNF) 对神经元可塑性和认知功能至关重要.
- 身体不活动与BDNF水平降低有关,可能会影响认知健康.
- 在不活动期间缺氧对BDNF的影响尚不清楚.
研究的目的:
- 为了研究控制的正常性低氧 (NH) 与身体不活动对血液BDNF水平的影响.
- 评估NH和不活动对执行职能的影响.
- 为了比较BDNF在normoxia (NOR) 下的变化与休息期间的NH.
主要方法:
- 一项随机控制的交叉研究,涉及25名健康成年人.
- 参与者进行了30分钟的休息阶段,随后进行了90分钟的NOR或NH (SpO2 85-80%).
- 血清和血BDNF水平,心率和SpO2被监测;暴露前后进行认知测试.
主要成果:
- NH显著降低了SpO2,并增加了心率.
- 在NOR下休息导致血清和血BDNF的显著减少.
- NH 阻止了在诺莫克西克不活性期间观察到的BDNF下降;在24小时的随访中,在两种条件下都显示了BDNF下降.
结论:
- 控制的正态缺氧 (NH) 可以减轻与身体不活动相关的BDNF的下降.
- 这些发现强调了身体活动对于维持最佳BDNF水平的重要性.
- 为了在血清和血中可靠地测量BDNF,需要标准化的协议.
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