维生素D可以减少炎症吗? 补充剂对选择免疫学标记物的影响
Martyna Lis1, Natalia Niedziela1, Jowita Adamczyk-Zostawa2
1Department of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.
International journal of molecular sciences
|July 27, 2024
概括
多发性硬化症 (MS) 患者的维生素D (VitD) 补充显示炎症标志物CXCL16,PTX3和OPG的增加. 即使是更高的剂量也没有显著改变促炎平衡.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 越来越多的证据表明,维生素D (VitD) 补充剂可以减轻多发性硬化症 (MS) 的炎症.
- 了解VitD对复发性复发性多发性硬化症 (RRMS) 特定炎症标志物的影响,对于治疗策略至关重要.
研究的目的:
- 研究不同维生素D (VitD) 剂量对RRMS患者关键炎症标志物的影响.
- 评估VitD补充后CXCL16,PTX3,ALCAM,IL-1RA和骨质保护素 (OPG) 血清度的变化.
主要方法:
- 一项为期六个月的研究涉及RRMS患者,分为高剂量 (2000 IU/天) 和低剂量 (15,960 IU/月) VitD组.
- 在基线和补充剂后测量了血清中25(OH) D和炎症标志物 (CXCL16,PTX3,ALCAM,IL-1RA,OPG) 的水平.
- 进行了统计分析,以评估组内和组间的变化以及与25...OH) D水平的相关性.
主要成果:
- 在6个月内,CXCL16,PTX3和OPG度的显著增加被观察到.
- 低剂量VitD组与高剂量组相比,PTX3和OPG的增加更大.
- 只有在研究开始时才注意到25(OH) D和PTX3/OPG之间的正相关性.
结论:
- 测试的维生素D (VitD) 剂量可能不足以显著调节RRMS患者的炎症和前炎症平衡.
- 可能需要进一步研究更高的VitD剂量或更长的干预期,以确定MS中明显的抗炎作用.
相关概念视频
Role of Skin in Vitamin D Synthesis
5.1K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.1K
Role of Vitamins in Maintaining Bone Health
3.2K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.2K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
331
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
331
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
149
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
149
Factors Affecting the Risk of Infection
11.5K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.5K


