在功能性胃肠道疾病中,受体间处理
Katerina Karaivazoglou1, Ioanna Aggeletopoulou2, Christos Triantos2
1Department of Psychiatry, University Hospital of Patras, 26504 Patras, Greece.
功能性胃肠道疾病 (FGIDs) 涉及改变的肠-大脑通信和整体感应. 审查了38项研究,我们发现FGID患者的内脏敏感性增加和大脑活动发生变化,这表明基于整感觉的治疗方法.
科学领域:
- 神经胃肠病学 神经胃肠病学
- 肠-大脑轴研究研究
- 互收研究 互收研究
背景情况:
- 功能性胃肠道疾病 (FGIDs) 影响全球许多人,呈现出没有明显病理的慢性症状.
- FGID通常与精神疾病同时发生,导致严重的痛苦和医疗负担.
- 肠-大脑轴调节失调和受体信号处理受损与FGID病理生理学有关.
研究的目的:
- 批判性地审查关于整体受理在FGIDs病理生理学中的作用的原始研究.
- 综合当前关于促进FGID发展和维护的整体感受机制的证据.
主要方法:
- 系统的文献搜索研究调查FGIDs中的整接收的研究.
- 分析了38篇精选的原创文章的研究结果.
- 包括神经成像,分子和遗传研究数据.
主要成果:
- FGID患者表现出增加的内脏敏感性和对肠道感觉的高度注意.
- 神经成像显示了FGID患者的整体受体网络中的结构和功能变化.
- 分子/遗传研究将整接收与神经传递,内分泌/免疫通路以及TRP通道基因表达联系起来.
结论:
- 互感处理变化是FGID病理生理学的核心.
- 基于interoception的干预措施有望减少FGIDs的症状和改善生活质量.
- 对于FGIDs,建议将以整体感受为重点的方法整合到临床管理中.
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