运动降低了葡萄糖不耐受,心脏炎症和脂肪组织功能障碍Psammomys obesus 暴露于短光周期和高能量饮食
Joanne T M Tan1,2, Kiara J Price1,2, Sarah-Rose Fanshaw1,2
1Vascular Research Centre, Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, SA 5000, Australia.
International journal of molecular sciences
|July 27, 2024
概括
运动改善葡萄糖代谢,并减少暴露在短时间白天和高能量饮食中的沙鼠的心脏炎症. 这些发现表明,运动可以预防糖尿病和心血管疾病,特别是轮班工作者.
科学领域:
- 代谢生理学 代谢生理学
- 时间生物学 时间生物学
- 运动科学运动科学
背景情况:
- 轮班工作中常见的循环节障碍会导致代谢障碍,如葡萄糖不耐受和心脏问题.
- 众所周知,运动可以改善新陈代谢健康并减少炎症.
- 沙鼠 (Psammomys obesus) 是研究代谢适应的相关模型,因为它们易受饮食诱导的肥胖和糖尿病的影响.
研究的目的:
- 研究运动对雄性沙鼠的葡萄糖代谢,心脏功能,脂肪组织和昼夜基因表达在模仿轮班工作的条件下 (短光周期和高能量饮食) 的影响.
主要方法:
- 雄性沙鼠接受了短时间的光周期 (5小时的光:19小时的黑暗) 和高能量的饮食,与静止控制组相比,运动干预组进行了运动干预.
- 测量包括葡萄糖耐受性测试,心脏基因表达 (炎症,亡,缩标志物),心脏组织和脂肪库的组织学分析,以及在上核和脂肪组织中的昼夜基因表达 (Bmal1,Per2).
- 评估了内脏和皮下脂肪组织中的关键分子介质.
主要成果:
- 运动显著降低了葡萄糖不耐受和心脏炎症 (降低了Ccl2,Bax:Bcl2比率).
- 在不改变肌细胞大小或纤维化的情况下,运动调节心脏缩标志物 (Myh7:Myh6增加,Gata4减少).
- 运动减少了内脏脂肪中的炎症标志物和脂肪生成/色调节剂,并减少了皮下脂肪中的脂肪细胞大小,同时影响了大脑和外围组织中的昼夜基因表达.
结论:
- 运动在昼夜干扰和高能量摄入的模型中提供了显著的代谢和心血管益处.
- 运动减轻心脏炎症,改善葡萄糖平衡,提供潜在的保护策略,防止代谢和心血管疾病.
- 研究结果强调,运动是对那些有昼夜节律障碍的个体,如轮班工人,至关重要的对策.
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