血中的炎症体适配蛋白ASC作为早期认知变化的生物标志物
Brianna Cyr1, Rosie Curiel Cid2, David Loewenstein2
1The Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami, Miami, FL 33136, USA.
International journal of molecular sciences
|July 27, 2024
概括
含有caspase招募域 (ASC) 的亡相关的斑状蛋白质显示,作为70岁以上个体早期认知衰退检测的血生物标志物具有前途. 在那些从正常认知转变为受损的人群中观察到高的ASC水平.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物发现发现
- 老年学是指老年学的学科.
背景情况:
- 痴呆症在全球影响着5700万人,预计到2040年发病率将翻一番,这凸显了对早期诊断工具的迫切需要.
- 在不可逆转的脑退化发生之前,早期发现认知障碍对于及时干预至关重要.
研究的目的:
- 研究血生物标志物的潜力,包括ASC,NfL,GFAP和Aβ42/40,用于早期检测老年人认知能力下降.
- 确定可靠的生物标志物,可以区分认知正常,过渡和认知障碍状态.
主要方法:
- 在基线时从老年人收集血样本,并分析ASC,NfL,GFAP和Aβ42/40.
- 根据两次年度评估,参与者被分为认知正常 (NN),认知正常然后受损 (NI) 和认知受损 (II) 组.
- 使用统计分析,包括曲线下的面积 (AUC),来评估生物标志物的性能.
主要成果:
- 与亡相关的斑状蛋白含有酶招募域 (ASC) 在NI组的血中显著升高,与NN和II组相比.
- 粉样β 42 (Aβ42) 在NI和II组的血中相对于NN组相对增加.
- 在70岁以上的个人中,ASC在区分NN和NI组时显示AUC为0.81,表明具有强大的诊断潜力.
结论:
- ASC是一种有前途的血生物标志物,可用于早期检测认知衰退,特别是在70岁以上的个体中.
- 升高的ASC水平可能会在显著的临床表现之前表明认知障碍的早期阶段.
- 需要进一步的研究来验证ASC作为痴呆症的常规诊断工具.
关键词:
在ASC中,ASC是ASC.阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.Aβ42 Aβ42 Aβ42 Aβ42 Aβ42 Aβ42 Aβ42 Aβ42 Aβ42皮卡德 (Pycard) 是一个名字.生物标志物生物标志物炎症导致的炎症.一些炎症一些炎症轻度的认知障碍 轻度的认知障碍更多相关视频
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