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多发性硬化症在体外模型中的概述

Joanna Czpakowska1, Mateusz Kałuża1, Piotr Szpakowski1

  • 1Department of Neurology and Stroke, Medical University of Lodz, Zeromskiego 113 Street, 90-549 Lodz, Poland.

International journal of molecular sciences
|July 27, 2024
PubMed
概括

本研究审查了多发性硬化症 (MS) 研究的体外模型,包括动物和人类细胞系,诱导多能干细胞 (iPSC) 和培养条件. 这些模型有助于理解多发性硬化病原和开发治疗方法.

关键词:
3D文化是一个3D文化.细胞培养培养的细胞培养.细胞模型的细胞模型.在体外 (in vitro) 的情况下.多发性硬化症多发性硬化症有机生物有机物多能干细胞是一种多能干细胞.球形状的球形体是指球形状的球体.

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EPS and iPS Cells in Disease Research01:21

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...