研究吸附和释放的多西环素化物从Zwitterionic微粒与carboxybetaine Moieties的吸附和释放
Stefania Racovita1, Marin-Aurel Trofin1, Ana-Lavinia Vasiliu1
1"Petru Poni" Institute of Macromolecular Chemistry, 41 A Grigore Ghica Voda Alley, 700487 Iasi, Romania.
紫微粒有效地从水中吸收了多西环素化物 (DCH). 这些新型支器具有高容量和受控释放,表明在医学和水净化方面有潜力.
科学领域:
- 材料科学 材料科学 材料科学
- 环境化学环境化学
- 制药科学 制药科学
背景情况:
- 抗生素耐药性需要新的药物输送和移除方法.
- 兹维特里昂材料为吸附和控制释放应用提供了独特的特性.
研究的目的:
- 评估zwitterionic微粒作为多西环素化物 (DCH) 吸附的宏分子支.
- 优化吸附条件并描述DCH的释放动力学.
主要方法:
- 吸实验进行了微粒剂量,pH值,接触时间,初始DCH度和温度的变化.
- 使用Lagergren,Ho,Elovich,Weber-Morris,Langmuir,Freundlich和Dubinin-Radushkevich模型进行了吸动力学和同热量分析.这些模型包括:
- 药物释放研究使用了希古奇,科尔斯迈耶-佩帕斯,贝克-隆斯代尔和科普查模型.
主要成果:
- 确定了最佳的吸附条件,产生了最大的吸附容量157.860 mg/g在308 K.
- 热力学分析表明,在更高的温度下,内热,自发和有利的吸收.
- 实验室释放研究显示DCH.的异常或非Fickian扩散机制.
结论:
- 兹威特微粒是高容量的DCH吸附的有效支持.
- 控制释放特征表明它适合用于制药应用.
- 这些材料在净化水和先进的药物输送系统中显示出DCH去除的前景.
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