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在老鼠中Galla chinensis的血管松和降压作用

Sujin Shin¹, Junkyu Park², Ho-Young Choi³

¹Department of Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.

International journal of molecular sciences

|July 27, 2024

概括

甘华50%乙醇提取物 (GCE) 在老鼠模型中显示出显著的血管松和低血压作用. 这项研究表明GCE是潜在的高血压自然治疗方法.

科学领域:

药理学药理学是指药理学的学科.
心血管研究研究心血管研究
自然产品医学自然产品医学

背景情况:

中华 (Galla chinensis) 具有已知的药用特性.
中华的抗高血压作用以前没有被研究过.
高血压仍然是一个重要的全球健康问题,需要新的治疗策略.

研究的目的:

为了研究Galla chinensis50%乙醇提取物 (GCE) 的血管松和低血压作用.
阐明GCE血管效应背后的机制.

主要方法:

用Sprague Dawley老鼠的大动脉片段来评估血管松剂活性.
在口服GCE的自发高血压大鼠 (SHRs) 中评估的低血压效应.
通过氧化/循环瓜诺辛3',5'-单酸盐通路,Ca2+通道抑制和K+通道激活探索的机制.

主要成果:

通过调节氧化通路,抑制Ca2+通道和激活K+通道,GCE表现出血管松作用.
口服GCE (100和300毫克/公斤) 在SHR中显著降低了静缩和静缩血压.
降低血压的持续时间高达给药后4小时.

结论:

GCE具有显著的血管松和低血压特性.
GCE代表了一种有前途的天然药物,用于高血压管理.
需要对长期GCE的使用和毒性概况进行进一步的研究.

关键词:

在中国,中国人吃了子.加拉中国人 (Galla chinensis) 是一个中国人.在NO/cGMP路径中.血压血压血压血压心血管疾病心血管疾病它们的内皮质 (endothelium).这种高血压,高血压.低血压的影响.自发高血压的老鼠血管放松剂血管放松剂

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