从甜到酸:SGLT-2抑制剂诱导的优糖性糖尿病酸性酸症
Andrijana Koceva1,2, Nika Aleksandra Kravos Tramšek1,2
1Department of Endocrinology and Diabetology, University Medical Center Maribor, Ljubljanska Ulica 5, 2000 Maribor, Slovenia.
Journal of personalized medicine
|July 27, 2024
概括
用于糖尿病和心脏/脏疾病的-葡萄糖共运输体2 (SGLT-2) 抑制剂,可以引起罕见的euglycemic糖尿病酸性酸症 (EDKA). 由于潜在的严重性,早期识别和管理至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- -葡萄糖共运输体2 (SGLT-2) 抑制剂是有效的抗高血糖剂,具有已确定的心脏脏保护益处.
- 它们的使用已经扩大到除了糖尿病之外,还用于管理心力衰竭和慢性病.
- 一种罕见但严重的副作用,SGLT-2抑制剂诱导的euglycemic糖尿病酸症 (EDKA),越来越多地报告.
研究的目的:
- 综合审查SGLT-2抑制剂诱导EDKA的病理生理学,临床表现和触发因素.
- 讨论EDKA目前的管理策略和预防措施.
- 提高对这种不良事件的认识并促进早期识别.
主要方法:
- 这是一个叙事评论.
- 关于SGLT-2抑制剂,EDKA,糖尿病酸性糖尿病以及相关的病理生理机制的文献搜索.
- 分析临床表现,诊断挑战和导致因素.
主要成果:
- SGLT-2 抑制剂通过葡萄糖和透性尿液诱导EDKA,导致碳水化合物缺乏和加速生成.
- EDKA与糖尿病酸性酸症类似,但缺乏高葡萄糖水平,延迟了诊断.
- 常见的触发因素包括疾病,手术和减少碳水化合物摄入量.
结论:
- 提高对与SGLT-2抑制剂相关的EDKA的认识对于及时诊断和管理至关重要.
- 及时识别诱发因素和适当的治疗对于预防严重后果至关重要.
- 预防策略应侧重于患者教育和风险因素修改.
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