泰国儿科患者的肠道微生物群和临床表现,这些儿童患有注意力缺陷多动性障碍
Jittraporn Panpetch1, Komsan Kiatrungrit2, Siriporn Tuntipopipat3
1Doctoral Program in Nutrition, Faculty of Medicine Ramathibodi Hospital and Institute of Nutrition, Mahidol University, Bangkok 10400, Thailand.
Journal of personalized medicine
|July 27, 2024
概括
在患有注意力缺陷多动症 (ADHD) 的儿童中,肠道细菌的形状不同. 像CAG-352这样的特定细菌与ADHD症状有关,而像Eubacterium hallii这样的其他细菌与较低的症状严重程度有关.
科学领域:
- 微生物组研究的研究.
- 神经发育障碍 神经发育障碍
- 儿科卫生保健 儿科卫生保健
背景情况:
- 注意缺陷多动症 (ADHD) 是一种神经发育障碍.
- 肠道功能障碍是导致ADHD的潜在因素.
- 了解肠道微生物组在ADHD中的作用对于开发新的治疗策略至关重要.
研究的目的:
- 为了比较患有ADHD的儿童和健康对照者的肠道微生物组成.
- 为了识别与ADHD症状相关的特定细菌属.
- 探索肠道细菌,ADHD症状严重程度和饮食摄入之间的潜在相关性.
主要方法:
- 对24名未接受过治疗的泰国多动症儿童和24名年龄/性别匹配的健康儿童进行了比较的横截面研究.
- 便样本的16S rRNA基因扩增序列测序,以分析微生物组成.
- 斯皮尔曼相关性分析用于评估细菌属,ADHD症状和营养摄入之间的关系.
主要成果:
- 在ADHD患者和对照人群之间没有观察到总体微生物多样性的显著差异.
- 患有ADHD的患者在*Alloprevotella*和*CAG-352*等属中表现出丰富.
- 健康的对照组具有较高的 * 巨 * 和 * 菌 hallii *.
- *CAG-352*与注意力不集中和多动性/冲动性得分正相关.
- *Eubacterium hallii* 和 *Megamonas* 与ADHD症状领域有负相关性.
- 贝塔胡卜素和维生素B2摄入量与特定的细菌属有关联.
结论:
- 特定的肠道微生物特征与儿童的ADHD有关.
- 肠道微生物组可能在ADHD病理生理学中发挥作用.
- 需要进一步的研究来澄清将肠道微生物群变化与ADHD临床生物标志物联系在一起的机制.
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