科尔奇辛-神圣的药物对抗COVID-19
1Department of Medical Chemistry and Biochemistry, Medical Faculty, Medical University-Sofia, 1431 Sofia, Bulgaria.
Journal of personalized medicine
|July 27, 2024
概括
较高的胆固醇剂量通过抑制白细胞中的NLRP3炎症酶显著降低了COVID-19患者的死亡率和住院治疗. 这种方法也减少了COVID-19后的症状,这表明病毒应用范围更广.
科学领域:
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
背景情况:
- COVID-19的特征是由髓状细胞驱动的失调炎症,特别是NLRP3炎症酶和随后的细胞因子风暴的过度激活.
- 之前对COVID-19的菌素的研究产生了相互矛盾的结果,原因是NLRP3炎症酶抑制在白细胞中的血清度不足.
- 世界卫生组织 (WHO) 建议不要在标准低剂量下使用科尔奇辛治疗COVID-19.
研究的目的:
- 在COVID-19患者中研究更高剂量的胆固醇在抑制NLRP3炎症和细胞因子风暴中的有效性.
- 评估这种治疗方案对死亡率,住院率和COVID-19后症状的影响.
主要方法:
- 向785名住院的COVID-19患者注射增加剂量的菌素.
- 用更高剂量的胆固醇治疗大批COVID-19门诊患者.
- 对治疗患者的死亡率,住院和COVID-19后症状发生率的分析.
主要成果:
- 在接受高剂量的素治疗的住院患者中,死亡率下降了两到七倍.
- 几乎100%的门诊患者用这种疗法治疗避免住院治疗.
- 在接受胆固醇的患者中,COVID-19后症状的发生率明显较低.
结论:
- 通过更高剂量在白细胞中达到微分子度的胆固醇可以有效地抑制NLRP3炎症酶/细胞因子风暴.
- 这种较高剂量的胆固醇治疗方案在减少COVID-19的严重程度和并发症方面显示出显著的益处.
- 这些研究结果表明,高剂量的胆固醇对于其他过度激活NLRP3炎症体的病毒感染,如流感等,具有潜在的有用性.
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