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在接受体外膜氧化治疗的COVID-19患者中出现多尿症

Johannes Rausch¹, Andrea U Steinbicker¹, Benjamin Friedrichson¹

¹Goethe University Frankfurt, University Hospital, Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, 60590 Frankfurt, Germany.

Journal of clinical medicine

|July 27, 2024

概括

多尿症,过度的尿液产生,发生在超过一半的COVID-19患者在静脉静脉外体膜氧化 (VV ECMO). 这种情况并没有显著影响患者的死亡率,尽管体液平衡和某些血液标志物在各组之间存在差异.

科学领域:

关键护理医学关键护理医学
腎臟病學 (nephrology) 是一種醫學.
传染性疾病传染性疾病

背景情况:

随着COVID-19的流行,人们越来越多地使用静脉静脉外体膜氧化 (VV ECMO).
临床观察指出,在接受VV ECMO的COVID-19患者中经常出现多尿症.
这项研究调查了多尿症在这个患者群体中的发生率,原因和影响.

研究的目的:

为了确定VV ECMO的COVID-19患者中多尿症的发生率.
探索在VV ECMO期间与多尿症相关的潜在因素.
评估多尿尿对这些患者死亡率的影响.

主要方法:

分析了接受VV ECMO的68名SARS-CoV-2阳性患者的队列.
患者被分为多尿症 (PU,尿量≥3000毫升/天) 和非多尿症 (NPU,<3000毫升/天) 组在ECMO启动后的七天内.
统计分析比较了各组之间的液体摄入量,平衡,肌素,血度,乳酸盐,尿素和水平.

主要成果:

多尿症发生在51.5%的患者在VV ECMO启动7天内.
在PU和NPU组之间没有观察到死亡率的显著差异 (60.0%和60.6%).
两组之间在液体摄入量,24小时液体平衡,肌素,血度,乳酸盐,尿素和水平上发现了显著差异. 在ECMO启动后,等离子度增加.

结论:

多尿是用VV ECMO治疗的COVID-19患者的常见发现.
多尿症似乎与这一队列的死亡率增加无关.
需要进一步的研究,以了解VV ECMO期间多尿症的机制和临床意义,用于COVID-19管理.

关键词:

在ARDS中,我们使用ARDS.在 COVID-19 疫情中,在ECMO中,可以使用ECMO.多尿症多尿症是什么意思

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