最近从轻度至中度的COVID-19中恢复过来的患者的心肌功能指数
Rafał Dankowski1, Wioletta Sacharczuk1, Julita Fedorowicz1
12nd Department of Cardiology, Poznan University of Medical Sciences, 60-485 Poznan, Poland.
Journal of clinical medicine
|July 27, 2024
概括
可检测到高敏感性托罗邦素I (hs-TnI) 的COVID-19幸存者显示全球工作效率 (GWE) 降低,全球浪费工作 (GWW) 增加. 应变分散 (PSD) 预测心肌效率低下,突出显示心脏收缩的时间中断.
科学领域:
- 心脏病学 心脏病学
- 心血管研究研究心血管研究
- 传染性疾病 传染性疾病
背景情况:
- 在COVID-19幸存者中发现了持续的心血管后续.
- 早期发现微妙的心肌损伤对于长期管理心脏健康至关重要.
- 心肌工作指数 (MW) 提供了心脏功能的敏感度量.
研究的目的:
- 评估最近从轻度至中度COVID-19中恢复过来的患者的心肌工作 (MW) 指数.
- 调查高度敏感的托罗邦素I (hs-TnI) 水平与MW指数之间的关联.
- 在COVID-19后的患者中确定心肌衰竭的预测因子.
主要方法:
- 最近康复的105名COVID-19患者 (平均年龄52岁) 接受了实验室检测和高级心声回声.
- 患者根据可检测和不可检测的高灵敏性托罗邦素I (hs-TnI) 水平进行了分层.
- 心肌工作指数 (MW),包括全球工作指数 (GWI),全球建设性工作 (GCW),全球浪费工作 (GWW) 和全球工作效率 (GWE),使用压力-应变循环进行评估.
主要成果:
- 可检测的hs-TnI在42%的患者中被发现.
- 检测到hs-TnI的患者表现出显著更高的GWW (168比97mmHg%,p<0.005) 和较低的GWE (93%比95%,p<0.005).
- 菌株分散 (PSD) 是GWW的唯一预测因素,也是GWE的重要预测因素,与LVEF一起.
结论:
- 最近轻度至中度COVID-19幸存者的hs-TnI水平升高与心肌效率受损 (减少GWE) 和浪费工作增加 (GWW) 相相关.
- 应变分散 (PSD) 成为心肌低效率和浪费工作的关键预测因素.
- 心肌收缩的时间和协调的障碍可能导致该队列心脏表现下降.
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