在患有活性类风湿性关节炎的女性中Syndecan-1水平
Norma Alejandra Rodriguez-Jimenez1, Fabiola Gonzalez-Ponce1, Jorge Ivan Gamez-Nava1,2
1Instituto de Terapeutica Experimental y Clínica, Programa de Doctorado en Farmacología, Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.
Journal of clinical medicine
|July 27, 2024
概括
类风湿性关节炎 (RA) 患者的血清syndecan-1水平高于患有活跃疾病的患者,而不是缓解期患者. 较高的syndecan-1对检测RA疾病活性具有良好的灵敏度,但特异性有限.
科学领域:
- 类风湿病学 类风湿病学
- 生物标志物 生物标志物
- 临床免疫学临床免疫学
背景情况:
- 血清葡萄糖蛋白syndecan-1与类风湿性关节炎 (RA) 疾病活动之间的关联仍然不清楚.
- 这项研究调查了与中度/重度RA疾病活性相关的血清中德坎-1度.
研究的目的:
- 评估血清中syndecan-1水平与类风湿性关节炎中中度/重度疾病活性之间的关联.
- 确定血清syndecan-1作为RA疾病活性生物标志物的有用性.
主要方法:
- 一项涉及75名RA成年女性和25名健康对照者的横截面研究.
- RA 患者被分为中度/重度疾病活动 (DAS28-ESR ≥3.2) 或缓解 (DAS28-ESR <2.6).
- 使用ELISA测量血清中的syndecan-1水平,高值的值为≥24 ng/mL.
主要成果:
- 患有RA的患者的血清中syndecan-1水平明显高于健康对照组 (p < 0.001).
- 与缓解期患者相比,具有活性疾病的RA患者的syndecan-1水平明显升高 (57.6vs23.5ng/mL,p=0.002).
- 高血清syndecan-1显示了84%的灵敏度和78%的疾病活动的积极预测值,但只有52%的特异性.
结论:
- 血清中syndecan-1水平升高与类风湿性关节炎疾病活动有关.
- 较高的syndecan-1显示出很好的灵敏度和积极的预测价值来识别活跃的RA,尽管特异性有限.
- 需要进一步的前性研究来探索syndecan-1在预测RA治疗失败方面的潜力.
相关概念视频
The JAK-STAT Signaling Pathway
8.8K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.8K
T Cell Types and Functions
967
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
967


