对NMIBC的当代治疗 - 是时候从BCG转向吗?
Rachel Passarelli1, Vignesh T Packiam2
1Division of Urology, Rutgers Robert Wood Johnson, New Brunswick, NJ 08901, USA.
Journal of clinical medicine
|July 27, 2024
概括
新的膀癌治疗方法正在出现,作为巴塞勒斯卡尔梅特-格林 (BCG) 治疗的替代方案. 组合疗法对非肌肉侵入性膀癌 (NMIBC) 患者有希望,可能改善结果并解决BCG短缺问题.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 癌症研究 癌症研究
背景情况:
- 非肌肉侵入性膀癌 (NMIBC) 占膀癌诊断的75%左右.
- 静脉内巴塞勒斯卡尔梅特 - 格林 (BCG) 是切割后的标准治疗方法,但复发率低于最佳水平.
- 治疗耐受性问题和BCG短缺需要探索替代疗法.
研究的目的:
- 在NMIBC中审查最近的文献和正在进行的临床试验,以寻找肠道BCG的替代品.
- 评估NMIBC新型治疗方式的疗效和安全性.
主要方法:
- 在PubMed的文献搜索中,查找关于BCG替代品的最新出版物.
- 在clinicaltrials.gov上搜索正在进行的NMIBC治疗试验.
- 对新出现的数据进行最近会议演讲的回顾.
主要成果:
- 结合性静脉内化疗显示了初步的疗效和安全性.
- 与BCG结合的静脉内疗法显示出良好的疗效和安全性.
- 与BCG结合的静脉注射疗法也显示出有前途的疗效和安全性.
结论:
- 新兴的组合疗法为NMIBC提供了标准BCG治疗的潜在替代方案.
- 目前正在进行的临床试验有望进一步完善NMIBC治疗策略.
- 随着试验数据的成熟,预计NMIBC治疗方案将发生转变.
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