运动不耐受与长期COVID-19综合征中的心血管功能障碍有关
Angelos Vontetsianos1, Nikolaos Chynkiamis1,2, Maria Ioanna Gounaridi3
1Rehabilitation Unit, 1st Respiratory Medicine Department, "Sotiria" Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Journal of clinical medicine
|July 27, 2024
概括
长期COVID-19综合征显著影响运动能力,与左心室和右心室功能受损有关. 心声图和运动测试显示了心脏表现和受影响患者的运动耐受性降低之间的关联.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
背景情况:
- 在长期COVID-19综合征中,心肺呼吸系统并发症很常见.
- 对运动能力的确切影响尚不清楚.
- 这项研究将心肺运动测试 (CPET) 与心声回声学联系起来,以评估长期COVID-19患者的运动耐受性.
研究的目的:
- 研究长期COVID-19对运动耐受性的影响.
- 结合CPET与休息回声心脏学数据进行全面评估.
- 在长期COVID-19中识别与运动不耐受相关的心脏参数.
主要方法:
- 42名长期COVID-19患者和10名健康对照人接受了休息心电回声和症状有限的CPET.
- 心声扫描评估了左心室缩功能 (LV-GLS,LVEF) 和腹缩功能 (E/e'比率).
- 评估了右心室缩性表现 (SRV) 和肺动脉缩性压力 (PASP).
主要成果:
- 与对照组相比,长期COVID-19患者表现出明显较低的LVEF和较大的左心室末缩直径.
- 扩张功能障碍 (E/e) 和升高的PASP与降低的峰值工作速度 (WRpeak) 和峰值氧气吸收 (VO2峰值) 相关.
- 右心室缩性表现 (SRV) 与WRpeak和VO2peak有很强的相关性.
结论:
- 长期COVID-19的运动不耐受与左心室透静功能受损和肺动脉静脉压升高有关.
- 在这些患者中,右心室缩性表现是运动能力的重要预测指标.
- 研究结果强调了长期COVID-19综合征中心脏功能和运动限制之间的复杂相互作用.
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