两个大型中枢透导管边缘到边缘修复装置的早期结果 - 一个倾向得分匹配的多中心比较
Philipp von Stein1, Hendrik Wienemann1, Jennifer von Stein1
1Department of Cardiology, Heart Center, Faculty of Medicine, University of Cologne, 50937 Cologne, Germany.
Journal of clinical medicine
|July 27, 2024
概括
帕斯卡和MitraClip XT(R/W) 装置在通过导管边缘到边缘修复后,显示了相似的技术成功和显著的额头吐减少. 在功能性MR患者中,PASCAL在实现严重的额头回减少方面表现出优势.
科学领域:
- 心脏病学 心脏病学
- 干预心脏病学 干预心脏病学
- 医疗器械 医疗器械
背景情况:
- 之前的研究表明,PASCAL和早期的MitraClip世代之间的结果是可比的.
- 对于当代的MitraClip世代,特别是大型的MitraClip XT (R/W) 存在有限的比较数据.
研究的目的:
- 用PASCAL P10与MitraClip XT (R/W) (第三/第四代) 来评估跨导管边缘到边缘修复 (M-TEER) 的急性和30天结果.
主要方法:
- 倾向性得分匹配从309名帕斯卡和253名MitraClip患者中创建了200对平衡对.
- 收集了最多30天的程序,临床和心声学结果.
- 进行了对 mitrale regurgitation (MR) 病因的子组分析.
主要成果:
- 这两种设备的技术成功率都很高 (PASCAL: 96.5%,MitraClip: 96.0%).
- 减少到MR ≤2+是可以比较的 (PASCAL:92.4%,MitraClip:87.8%).
- 帕斯卡显示了较高的减少率到MR ≤1+ (67.7%对比56.6%),特别是在功能性MR (FMR) 患者中 (74.0%对比60.0%).
结论:
- 两种M-TEER设备都表现出高度的技术成功和可比的MR减少到≤2+.
- 在患有FMR的患者中,PASCAL可能在实现MR降低至≤1+方面具有优势.
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