抗生素耐药性趋势在腺炎补充性病变中的趋势
Dimitra Koumaki1, Georgios Evangelou1, Sofia Maraki2
1Dermatology Department, University Hospital of Heraklion, Heraklion, 711 10 Crete, Greece.
Journal of clinical medicine
|July 27, 2024
概括
抗生素耐药性是 hidradenitis suppurativa (HS) 管理中的一个重要问题. 这项研究发现,从HS病变中分离出来的细菌中对常见抗生素的耐药性高,因此需要更新治疗指南.
科学领域:
- 皮肤病学 皮肤病学
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗生素治疗是对补腺炎 (HS) 的首要治疗方法.
- 了解局部抗菌素耐药性模式对于有效的HS管理至关重要.
- 这项研究调查了HS患者的抗生素耐药性.
研究的目的:
- 为了评估抗生素耐药性的流行在细菌分离物从患有 hidradenitis suppurativa的患者.
- 为HS治疗提供适当的抗微生物选择信息.
主要方法:
- 一项涉及希腊赫拉克利昂大学医院103名HS患者的横截面研究.
- 在皮肤病变的质物质上进行了细菌培养和抗生素图谱分析.
- 患者的选择是基于在前三个月没有使用抗生素.
主要成果:
- 在139个皮肤病变中的79.86%发现了细菌.
- 观察到高耐药率:57.1%的levofloxacin和53.3%的青素在*Staphylococcus lugdunensis*; 76.9%的青素和58.3%的酸在*Staphylococcus aureus*.
- 在格拉姆阴性分离物 (例如63.5%对tigecycline) 和无气体 (例如62.5%对红素) 中发现了显著的耐药性.
结论:
- 患有HS的患者在细菌分离物中表现出相当大的抗生素耐药性.
- 目前对HS的治疗指南需要修订,以纳入这些关于细菌抗生素耐药性的发现.
- 当地耐药性数据对于优化HS治疗策略至关重要.
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