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在COVID-19患者中评估氧化应激和内皮功能障碍

Nurcan Kırıcı Berber¹, Osman Kurt², Ayşegül Altıntop Geçkil¹

¹Department of Chest Diseases, Malatya Turgut Özal University, Malatya 44210, Turkey.

Medicina (Kaunas, Lithuania)

|July 27, 2024

概括

不对称二甲基氨酸 (ADMA) 和热冲击蛋白-90 (HSP-90) 的血清水平可以预测严重的COVID-19. 较高的ADMA和HSP-90表明COVID-19患者内皮损伤增加和严重疾病风险增加.

科学领域:

生物化学生物化学
免疫学免疫学免疫学
病毒学病毒学

背景情况:

热冲击蛋白 (HSP) 是应激蛋白,涉及到细胞防御机制.
非对称二甲基氨酸 (ADMA),一种内源性氧化合成酶抑制剂,是内皮功能障碍的关键调解剂.
已知严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染会导致内皮功能障碍,炎症和凝血病.

研究的目的:

调查血清ADMA和HSP-90水平的预后价值,用于早期预测严重的COVID-19.
分析COVID-19患者的ADMA,HSP-90水平和内皮损伤之间的相关性.

主要方法:

一项涉及76名COVID-19患者和35名健康对照者的病例控制研究.
COVID-19患者被分为轻度和重度疾病组.
血清ADMA和HSP-90水平使用后勤回归和接收器操作特征 (ROC) 曲线分析来量化和分析.

主要成果:

与对照组相比,COVID-19患者的血清ADMA和HSP-90水平显著升高 (p < 0.001).
严重的COVID-19病例显示ADMA和HSP-90水平明显高于轻度病例 (p < 0.001).
无论是ADMA (OR = 1.099) 还是HSP-90 (OR = 5.296) 都是严重COVID-19的独立预测因素,具有高灵敏度和特异性 (AUC> 0.93).

结论:

高血清HSP-90和ADMA水平与COVID-19中的内皮损伤增加相关.
ADMA和HSP-90作为潜在的预后生物标志物,用于识别患有严重COVID-19高风险的患者.
针对内皮功能障碍的治疗策略可能会改善COVID-19患者的治疗结果并降低死亡率.

关键词:

在 COVID-19 疫情中,内皮质功能障碍内皮质功能障碍热冲击蛋白质是一种热冲击蛋白质.氧化应激是一种氧化应激.

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