工作压力与内皮功能障碍标志物和成像介导的缺血性心脏病之间的关系
Paloma Moisii1,2, Irina Jari3,4, Andra Mara Ursu4
11st Medical Department, "Gr.T.Popa" University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania.
工作压力,一种工作场所的压力,显著提高高灵敏度C反应蛋白 (hs-CRP) 和白蛋白尿液分泌率 (AUER),这是心血管风险的关键指标. 建议减少工作压力的干预措施,以预防冠状动脉疾病.
科学领域:
- 心脏病学 心脏病学
- 职业健康 职业健康 职业健康
- 精神病体医学是一种精神病体医学.
背景情况:
- 工作压力是一个重要的工作场所压力因素,与冠状动脉疾病 (CAD) 的风险增加一倍以上有关.
- 了解与工作压力相关的生理标记对于心血管风险评估和预防策略至关重要.
研究的目的:
- 调查工作压力与特定生物标志物之间的关联:高灵敏度C反应蛋白 (hs-CRP) 和白蛋白尿液分泌率 (AUER).
- 探索工作压力和二级心脏病评估之间的关系,包括心电图 (ECG),心声图和增强对比计算断层扫描 (ECCT).
主要方法:
- 一项涉及210名参与者的描述性横截面研究 (105名慢性冠状动脉综合征患者和105名没有慢性冠状动脉综合征患者),评估时间为2023年10月至2024年2月.
- 收集的数据包括基线特征,hs-CRP,AUER,ECG,心声学,ECCT和心理问卷 (抑郁症的PHQ-9,工作压力的SWWS).
- 进行了统计分析,以确定工作压力,生物标志物和心脏成像发现之间的显著关联.
主要成果:
- 在CCS和非CCS组中,工作压力与hs-CRP水平升高 (p < 0.001) 和AUER增加 (p < 0.001) 显著相关.
- 在工作压力和心电图异常 (ST抑郁,T波,q波;p < 0.001) 之间发现了显著的关联,心电图发现 (p = 0.018) 和心电图结果 (p = 0.005).
- 抑郁症经常被诊断在工作压力的人群中,与冠状动脉化 (p = 0.013) 和CCS状态 (p = 0.021) 有着显著的关联.
结论:
- 工作压力是导致hs-CRP和AUER升高的重要因素,表明炎症和内皮功能障碍增加.
- 该研究强调了工作压力对心血管健康的不利影响,其与客观心脏参数的关联证明了这一点.
- 建议将工作压力减轻策略整合到冠心病 (CHD) 的初级和二级预防计划中.
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