患有腹腔疾病的绝经前妇女的骨健康:一项观察性研究
Katie Schraders1, Jane Coad1, Marlena Kruger2
1School of Food Technology and Natural Sciences, College of Sciences, Massey University, Palmerston North 4442, New Zealand.
在不含谷蛋白饮食 (GFD) 上,经过DXA的绝经前女性患有乳病 (CD) 没有显示骨矿物质密度 (BMD) 的差异. 然而,定量超声波 (QUS) 表明CD.妇女的骨质质量较差.
科学领域:
- 胃肠病学 胃肠病学
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 低骨矿物质密度 (BMD) 普遍存在于腹腔疾病 (CD) 患者中,即使是在无质饮食 (GFD) 中.
- 绝经前妇女患有CD和先前存在的低BMD面临骨质疏松症风险增加.
- 患有CD的女性的骨健康需要进一步调查,特别是关于饮食和骨质的质量.
研究的目的:
- 为了比较骨矿物质密度 (BMD) 和前更年期妇女的骨质质量,在GFD上CD与健康对照.
- 评估这些群体的骨代谢,营养状况和饮食摄入量.
- 为了确定GFD粘附是否减轻了患有CD的女性的骨密度损失.
主要方法:
- 使用双X射线吸收测量 (DXA) 测定骨硬化和定量超声波 (QUS) 测定骨质.
- 骨代谢标志物和营养状况被生物化学评估.
- 四天的饮食日记量化了营养摄入量,重点关注能量,纤维,,和.
主要成果:
- 在CD和对照女性之间,在BMD (部,腰椎,前臂) 中没有发现显著差异.
- 在患有CD的女性中,定量超声波 (QUS) 参数明显较低,表明骨质量下降.
- 患有CD的女性饮食中能量,纤维,和的摄入量较低;这两组都摄入不足的.
结论:
- 在新西兰,骨髓质量和骨生物标志物在患有乳和健康女性之间没有差异.
- 定量超声波 (QUS) 可能在检测结核病中的骨变化方面更敏感,因为它对骨的影响.
- 需要进一步的研究,以探索QUS的实用性和在GFD上的乳病患者的特定骨变化.
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