"阳光维生素"及其抗氧化剂有益于增强肌肉功能
Cristina Russo1, Rosa Santangelo2, Lucia Malaguarnera1
1Section of Pathology, Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, 95123 Catania, Italy.
Nutrients
|July 27, 2024
概括
氧化应激和炎症会损害肌肉功能,可能导致肉症. 维生素D具有抗氧化特性,可以通过对抗这些影响来帮助保持肌肉健康.
科学领域:
- 肌肉生理学 肌肉生理学
- 营养生物化学 营养生物化学
- 细胞还氧化生物学 细胞还氧化生物学
背景情况:
- 氧化应激和全身炎症会降低肌肉细胞的功能,导致衰弱,代谢障碍和肉症.
- 骨肌肉的健康取决于环境,营养,身体和遗传因素,饮食和运动对组织完整性至关重要.
- 维生素D缺乏在全球普遍存在,与氧化损伤,线粒体功能障碍,ATP生产减少和肌肉功能受损有关.
研究的目的:
- 探索维生素D影响肌肉中氧化应激的分子机制.
- 评估维生素D补充剂在氧化应激和炎症期间保护肌肉功能方面的潜力.
主要方法:
- 文献综述侧重于维生素D作用的分子机制.
- 对维生素D缺乏和肌肉健康的流行病学数据的分析.
- 关于维生素D在减轻氧化应激和肌肉炎症中的作用的综合证据.
主要成果:
- 维生素D表现出对骨肌肉维护至关重要的抗氧化特性.
- 维生素D缺乏与氧化损害增加和肌肉性能降低相关.
- 该评论详细介绍了维生素D对受氧化应激影响的分子通路的调节.
结论:
- 维生素D在骨肌肉功能中起着至关重要的作用,部分是通过其抗氧化作用.
- 解决维生素D缺乏症可能是对抗肌肉功能障碍的可行策略.
- 需要进一步研究维生素D补充剂对于炎症和氧化条件下的肌肉健康.
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