在老鼠中,四种元素铁粉的血红蛋白再生效率和相对铁的生物可用性
James H Swain1, Ryan C Nemeth2, Anshul R Bethi2
1Department of Nutrition, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.
Nutrients
|July 27, 2024
概括
基本铁粉 (EIPs) 通过提高血红蛋白再生效率,有效地对抗缺铁性贫血. 四个食品级EIP在贫血的老鼠模型中显示出相当于硫酸铁的铁的显著生物可用性.
科学领域:
- 营养科学 营养科学
- 生物化学 生化学
- 食品科学 食品科学 食品科学
背景情况:
- 缺铁性贫血仍然是一个重大的全球健康问题,需要有效的食品强化策略.
- 元素铁粉 (EIPs) 是潜在的强化剂,但它们的有效性需要彻底评估.
- 了解EIPs的血红蛋白再生效率 (HRE) 和相对铁生物利用率 (RBV) 对于开发成功的干预措施至关重要.
研究的目的:
- 为了确定四种食品级EIP的HRE和RBV:El-Lyte (EL),Hi-Sol (HS),H-325 (H3) 和A-131 (A1).
- 在贫血大鼠模型中比较EIPs对硫酸铁 (FS) 的疗效.
- 评估和铁溶解度对EIP生物可用性的影响.
主要方法:
- 贫血大鼠在14天内食各种铁度 (12,24,36毫克/公斤) 的EIP或FS强化饮食.
- 在一项为期6周的维护研究中,使用EL和HS在6毫克/公斤铁中监测血红蛋白水平.
- 在盐酸 (pH1.0) 中测量铁溶解率,以与RBV相关联.
主要成果:
- 与FS相比,EL,HS和A1 EIP的整体RBV超过50%,HS>A1>EL>H3 (p ≤0.05) 的顺序.
- 对铁的生物可用性没有显著影响 (p > 0.05).
- 较高的铁溶解度与EIPs的平均RBV增加正相关;EL和HS保持了与FS相比的血红蛋白水平.
结论:
- 食品级元素铁粉,特别是HS,A1和EL,是补充血红蛋白和纠正缺铁性贫血的有效药物.
- 在测试条件下,这些EIP的生物可用性与硫酸铁的生物可用性相当或超过.
- 铁的溶解度是EIP生物可用性的关键预测因素,支持其在食品强化中的使用.
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