微生物组在慢性肠衰竭中是否重要?由于成人1型短肠综合征?
Marta Ossola1, Ilario Ferrocino2, Irene Franciosa2
1Dietetic and Clinical Nutrition Unit, Città della Salute e della Scienza Hospital, C.so Bramante 88, 10126 Torino, Italy.
Nutrients
|July 27, 2024
概括
短肠综合征 (SBS) 和慢性肠衰竭 (CIF) 患者的微生物组分析揭示了关键关联. 增加的乳酸菌与胃输出有关,而纤维摄入量和SCFA Ester与1型SBS-CIF患者的过有关.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
- 代谢学 代谢学 代谢学
背景情况:
- 微生物组在短肠综合征 (SBS) 和慢性肠衰竭 (CIF) 中的作用尚不清楚,特别是在1型SBS-CIF患者中,这些患者有末端结节管/结节管.
- 了解这些微生物和代谢特征对于管理复杂的胃肠道疾病至关重要.
研究的目的:
- 调查成人1型SBS-CIF患者的便微生物组合和挥发性有机化合物 (VOC) 概况.
- 为了将这些发现与临床特征相关联,例如胃输出量,小肠长度,超和食纤维摄入量.
主要方法:
- 使用基于amplicon的测序进行便微生物群分析.
- 通过固态微提取和气相色谱-质谱测量评估挥发性有机化合物 (VOC).
- 在44名成人1型SBS-CIF患者的微生物/代谢数据和临床参数之间的统计相关性分析.
主要成果:
- 乳杆菌科和链球菌科家族,特别是乳杆菌和链球菌属,占主导地位.
- 较高的乳酸菌丰度与胃输出量增加相关 (p=0.010).
- 过与短链脂肪酸 (SCFA) (例如,丁酸乙烯,p=0.005) 和食纤维摄入量 (p=0.040) 的增加有关.
结论:
- 在1型SBS-CIF中,增加的乳酸菌频率与更高的胃输出有关.
- 饮食纤维摄入量和SCFA Ester度与过有关.
- 这些发现可能会为SBS-CIF患者的临床管理策略提供信息.
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