腹腔营养,炎症性肠病和肠道屏障:一个复杂的情节
Carlo Covello1, Guia Becherucci2, Federica Di Vincenzo1
1Gastroenterology Department, Centro di Malattie dell'Apparato Digerente (CEMAD), Center for Diagnosis and Treatment of Digestive Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
Nutrients
|July 27, 2024
概括
腹腔营养,对于管理炎症性肠道疾病的营养不良至关重要,对肠道系统产生负面影响. 需要进一步的研究来澄清这些对肠道健康和微生物群的影响.
科学领域:
- 胃肠病学 胃肠病学
- 营养科学 营养科学
- 微生物学 微生物学
背景情况:
- 营养不良是炎症性肠病 (IBD) 的重要并发症.
- 亲肠道营养 (PN) 对特定的IBD相关疾病,如短肠综合征和肠道抽,至关重要.
- 在IBD中PN对肠道屏障和肠道微生物群的影响是正在进行的调查领域.
研究的目的:
- 审查和分析现有的临床前和临床研究关于PN对IBD肠道屏障和肠道微生物群的影响.
- 综合当前关于IBD患者短期和长期PN后果的证据.
主要方法:
- 叙述性审查方法.
- 包括从临床前 (动物) 和临床 (人类) 研究中得出的结果.
- 对肠道屏障功能,粘膜完整性和肠道微生物组成数据的分析.
主要成果:
- 有证据表明,短期和长期PN与不良肠道影响之间存在相关性.
- 观察到的负面影响包括粘膜缩,免疫和神经内分泌失调,以及肠道屏障透性的改变.
- 在使用PN时,发现了肠道微生物群组成的显著变化.
结论:
- 在IBD的背景下,亲肠营养与肠道系统的有害变化有关.
- 这些PN诱导的IBD病原体变化的精确机制作用仍然未确定.
- 需要进一步进行全面的研究,以解决知识差距,并阐明PN在IBD中的全部影响.
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