维生素D和炎症和自身免疫性风湿性疾病中的肌肉状况:最新情况
Elvis Hysa1,2, Emanuele Gotelli1, Rosanna Campitiello1,3
1Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Viale Benedetto XV, 6, 16132 Genoa, Italy.
Nutrients
|July 27, 2024
概括
低维生素D水平在风湿性疾病中很常见,并且与肌肉健康不佳有关. 维持足够的维生素D可能会保护肌肉,但需要更多的研究来确定最佳的补充策略.
科学领域:
- 类风湿病学 类风湿病学
- 内分泌学 在内分泌学.
- 肌肉生理学 肌肉生理学
背景情况:
- 维生素D对于平衡和骨健康至关重要.
- 新出现的证据强调了维生素D在肌肉功能和免疫反应调节中的作用.
- 维生素D状况下降可能会对类风湿症患者的肌肉效率产生负面影响.
研究的目的:
- 审查维生素D缺乏对炎症性和自身免疫性类风湿性疾病中的肌肉功能的影响.
- 探索维生素D在免疫介导机制和间接过程中的作用,例如影响骨肌肉的皮症.
- 综合现有证据,将维生素D状态与常见的类风湿性疾病中的肌肉健康联系起来.
主要方法:
- 使用"维生素D,肌肉,类风湿性疾病" (MeSH术语) 进行了PubMed和Medline的全面文献搜索.
- 包括最近的会议摘要 (EULAR,ACR 2020-2023) 和参考列表扫描.
- 重点是过去五年的证据,并补充了早期的重要研究.
主要成果:
- 在异形性炎症性肌肉病,多发性肌痛性疼痛,类风湿性关节炎,红斑狼和全身性硬化症中观察到的维生素D缺乏/不足的高患病率.
- 维生素D不足与肌肉强度降低,疼痛增加,疲劳增加以及某些自身免疫性疾病中较高的疾病活性有关.
- 维生素D代谢物显示出降低炎症和增强肌肉再生,新陈代谢和线粒体功能的潜力,尽管干预数据有限.
结论:
- 改变维生素D状态在炎症性和自身免疫性类风湿性疾病中很常见,与不利的肌肉健康结果相关.
- 适当的维生素D水平可以提供肌肉保护的好处.
- 进一步的研究是必要的,以验证这些协会,并确定最佳的维生素D补充策略为类风湿患者.
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