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后COVID-19食欲的变化-一个探索性研究
Georgeta Inceu1,2, Ruben Emanuel Nechifor3, Adriana Rusu1,2
1Department of Diabetes and Nutrition Diseases, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.
Nutrients
|July 27, 2024
概括
COVID-19 感染可能会通过增加胃口激素,如 ghrelin 和神经 Y (NPY) 来改变饮食行为. 这些变化与食欲调节区域的大脑活动相关,在感染后持续存在.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 心理学 心理学 心理学
背景情况:
- COVID-19已与各种长期健康影响有关.
- 饮食行为是一个复杂的过程,受荷尔蒙和神经信号的影响.
- 对于COVID-19对食欲调节的影响仍然不完全理解.
研究的目的:
- 调查COVID-19对饮食行为和食欲调节的持续影响.
- 为了比较与食欲相关的荷尔蒙特征和大脑活动,在有和没有COVID-19病史的人群中比较.
主要方法:
- 对来自两个组的55名成年人 (<50岁,没有超重/肥胖) 的横截面分析:非COVID-19 (n=27) 和COVID-19病史 (n=28).
- 评估了饥饿,饮食行为 (TFEQ-18),血格林,神经Y (NPY) 和休息状态功能性MRI (fMRI).
- 使用基于voxel的区域同质性 (ReHo) 和神经元同步性和连接性的中心度 (DC) 来分析大脑活动.
主要成果:
- 与非COVID-19组相比,COVID-19组的血 ghrelin (197.5 vs. 67.1 pg/mL) 和NPY (128.0 vs. 84.5 pg/mL) 水平显著更高 (分别为p < 0.001和p = 0.005).与非COVID-19组相比,COVID-19组的血 ghrelin (197.5 vs. 67.1 pg/mL) 和NPY (128.0 vs. 84.5 pg/mL) 水平显著更高.
- NPY水平与左舌环中的ReHo和DC正相关,这是参与食欲调节的区域.
- 两组之间的认知克制,不受控制的饮食或情绪饮食得分没有显著差异 (p > 0.05).
结论:
- 在COVID-19感染后长时间观察到食欲相关激素 (ghrelin,NPY) 的持续升高.
- 增加的NPY水平与控制食欲的大脑区域神经活动的改变有关.
- 尽管饮食行为模式稳定,但COVID-19可能会导致食欲神经内分泌调节的持久变化.
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