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开发和评估具有抗生素作用的生物转化牛奶,对牙周病原体和α-葡萄糖酶抑制活性产生抗菌作用

Yewon Lee¹, Yohan Yoon^1,2, Kyoung-Hee Choi³

¹Risk Analysis Research Center, Sookmyung Women's University, Seoul 04310, Republic of Korea.

|July 27, 2024

概括

益生菌和药用植物如Artemisia herba-alba可以对抗牙周病原体. 使用 Lactiplantibacillus plantarum SMFM2016-RK 和 A. herba-alba 提取物进行生物转化牛奶显示出对口腔健康和血糖控制的前景.

科学领域:

微生物学微生物学
食品科学食品科学食品科学
药理学药理学是指药理学的学科.

背景情况:

益生菌和微生物生物转化是管理口腔微生物群和相关疾病的新兴策略.
阿尔特梅西亚草 (Artemisia herba-alba) 含有具有潜在治疗应用的生物活性化合物.
功能性食品中益生菌和药用植物提取物的协同作用正在引起研究兴趣.

研究的目的:

开发和评估含有Artemisia herba-alba和选定的益生菌菌株的生物转化牛奶.
评估生物转化牛奶在抑制关键牙周病原体和α-葡萄糖酶活性方面的有效性.
描述益生菌菌株Lactiplantibacillus plantarum SMFM2016-RK及其基因组特征.

主要方法:

对74种乳酸细菌菌株进行查,以确定合适的益生菌,Lactiplantibacillus plantarum SMFM2016-RK,基于酸/胆耐受性,抗氧化剂和α-葡萄糖酶抑制活性.
使用L. plantarum SMFM2016-RK单独或与不同度的A. herba-alba乙醇和热水提取物结合制备四种生物转化乳制剂 (BM1-BM4).
对牙周病原体 (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Fusobacterium nucleatum) 的抗菌活性评估和α-葡萄糖酶抑制试验.
全基因组测序和L. plantarum SMFM2016-RK的注释,以确定相关的代谢途径.

主要成果:

乳植物菌植物 SMFM2016-RK 显示出显著的酸和胆汁耐受性,抗氧化活性和α-葡萄糖酶抑制.
含有A. herba-alba提取物 (BM2,BM3,BM4) 的生物转化牛奶配方与单独的益生菌 (BM1) 相比,表现出更强的牙周病原体抑制.
特定配方对不同的病原体表现出强烈的抑制作用:BM3对抗A. actinomycetemcomitans和P. gingivalis,BM4对抗F. nucleatum.
有A. herba-alba的生物转化牛奶显示出优异的α-葡萄糖酶抑制活性.

结论:

由L. plantarum生物转化的Artemisia herba-alba添加的牛奶SMFM2016-RK有效地抑制牙周病原体和α-葡萄糖酶.
开发的功能性食品具有管理牙周病和改善血糖控制的潜力.
进一步的体内研究是有必要的,以验证这些发现在动物模型.

关键词:

阿尔特梅西亚草本 - 阿尔巴巴生物转化牛奶的生物转化牛奶牙周病原体牙周病原体益生菌是一种益生菌.α-葡萄糖化酶的使用

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