成人和儿童的殖民化:一个前性研究
Lucia Moro1, Giorgio Zavarise2, Giada Castagna3
1Department of Infectious, Tropical Diseases and Microbiology, I.R.C.C.S. Sacro Cuore Don Calabria Hospital, 37024 Negrar di Valpolicella, VR, Italy.
Microorganisms
|July 27, 2024
概括
(T. whipplei) 的殖民可以持续多年,有些人表现出超过六年的积极结果. 在持续的T. whipplei殖民和起源,治疗或共感染之间没有发现任何联系.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 特洛菲里玛·惠普莱 (Tropheryma whipplei) 是一种已知会引起惠普尔病的细菌.
- 影响T. whipplei殖民的持续时间和因素尚不清楚.
研究的目的:
- 为了调查T. whipplei殖民的持续时间,先前发现T. whippleiDNA阳性的人.
- 评估持续殖民和原产地大陆,治疗,临床表现和寄生虫共感染之间的相关性.
主要方法:
- 一项前性队列研究,涉及33名先前阳性T. whipplei便DNA测试的受试者.
- 在基线和12个月收集便,唾液,尿液和血液样本.
- 记录病史,当前治疗和症状.
主要成果:
- 25%的受试者表现出持续的肠道或口腔T. whipplei殖民.
- 50%的人在两次访问中都没有出现殖民,25%的人间断地出现殖民.
- 持续的殖民持续时间在某些情况下超过六年;没有发现与起源,治疗或共感染的关联.
结论:
- T. whipplei的殖民可以持续长时间 (超过六年).
- 持续的殖民化与人口,临床或共感染因素之间没有明确的关联.
- 需要进一步研究菌株特异性识别,以了解其持久性和健康影响.
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