血细胞因子和微生物组概况的种族差异
Kevin D Fan1,2, Elizabeth Ogunrinde3, Zhuang Wan1
1Department of Microbiology & Immunology, Medical University of South Carolina, 173 Ashley Ave. Basic Science Building BS208F, Charleston, SC 29425, USA.
Microorganisms
|July 27, 2024
概括
非洲裔美国人 (AA) 呈现较高的血IL-6水平,与特定的肠道细菌如Actinomyces有关,这表明微生物组转移驱动炎症. 这种血液微生物组与IL-6的联系可能会提供新的精准医学方法.
科学领域:
- 微生物组研究的研究.
- 炎症生物学 炎症生物学
- 免疫学 免疫学 免疫学
背景情况:
- 非洲裔美国人 (AA) 种群的慢性炎症疾病发病率很高.
- 血微生物组转位被研究为慢性炎症的潜在触发因素.
研究的目的:
- 调查健康的非裔美国人 (AA) 和白人美国人 (CA) 之间血微生物组合和细胞因子水平的差异.
- 为了探索血中的特定细菌属和Interleukin-6 (IL-6) 水平之间的关联.
主要方法:
- 招募了16名CA和22名AA健康参与者.
- 在血微生物DNA上进行了16S rRNA V3-4测序.
- 量化33种血细胞因子和化学因子.
- 在实验室中使用人类THP-1细胞验证的亲炎性微生物组.
主要成果:
- 与CA个体相比,AA个体的IL-6,IL-15,MIP-1α,MIP-1β和MIP-3α的血水平较高.
- 八个细菌系/细菌系在AA与CA等离子体中差异丰富.
- 动菌的丰度与血IL-6正相关,而库尔提亚,诺维赫巴斯皮里勒姆,Candidatus Protochlamydia和雷兰氏菌的丰度与阴性相关.
- 在体外,Actinomyces物种在THP-1细胞中诱导了更高的IL-6产生.
结论:
- 这项研究是首次表明血微生物组转位是健康AA个体中IL-6升高的驱动因素,与CA个体相比.
- 了解血微生物组和IL-6关联的种族差异对于开发有针对性的治疗策略至关重要.
- 这些发现支持了针对个体微生物组形状和炎症标志物量身定制的精密医学方法的潜力.
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