在控制药物释放的医疗级金属基板上涂上纤维素酸和聚烯酸纤维涂层
Catarina Cidade do Carmo1, Miguel Brito1, J P Oliveira1
1CENIMAT|i3N, Department of Materials Science, NOVA School of Science and Technology, NOVA University Lisbon, 2829-516 Caparica, Portugal.
Polymers
|July 27, 2024
概括
这项研究开发了金属植入物具有成本效益的多层涂层,以防止生物膜的形成. 素中间层显著改善了粘附性,特定的涂层组合显示出控制药物释放的潜力,增强了植入物寿命.
科学领域:
- 生物材料科学 生物材料科学
- 表面化学 表面化学
- 药物输送系统 药物输送系统
背景情况:
- 金属假肢上的生物膜形成导致拒绝和更换.
- 开发成本有效的方法来抑制生物膜的形成对于植入物寿命至关重要.
- 布洛芬 (Ibu) 是一种广泛使用的抗炎药物,适用于药物释放研究.
研究的目的:
- 探索具有成本效益的多层涂层,以抑制金属假肢上的生物膜形成.
- 为了评估酸盐中间层对不钢涂层粘附性的影响.
- 为了研究不同涂层配置的伊布罗芬药物释放配置.
主要方法:
- 用纤维素 (CA),聚烯酸 (PCL) 和奇托 (CHI) 的多层涂层被应用到SS-316上,使用电,电喷涂或吹.
- 涂层粘附度是用牛顿 (N) 来测量的.
- 在模拟体液 (SBF) 中介中研究药物释放.
主要成果:
- 与没有基托 (0.150.22 N) 的涂层相比,基托中间层显著增加了涂层对不钢基板的粘附度 (0.210.74 N).
- 药物释放主要是通过所有涂层的扩散驱动的.
- 在用布洛芬涂覆的纤维素酸涂层中观察到延迟的布洛芬释放,当随后通过吹覆盖聚烯酸时.
结论:
- 多层涂层,特别是含有奇托的涂层,有望提高金属植入物的性能.
- 涂料的特定组合,如CA/PCL,可以调节药物释放动力学,这表明有潜在的可控抗炎药物递送.
- 对优化的多层涂层设计进行进一步的研究是有必要的,以提高生物膜抑制和药物输送.
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